Running and the development of disability with age

J. F. Fries, G. Singh, D. Morfeld, H. B. Hubert, Nancy E Lane, B. W. Brown

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

Objective: To determine, by longitudinal study, whether regular vigorous running activity is associated with accelerated, unchanged, or postponed development of disability with increasing age. Study design: 8-year prospective, longitudinal study with yearly assessments. Participants: 451 members of a runners' club and 330 community controls who were initially 50 to 72 years old (also characterized as 'ever-runners' [n = 534] and 'never-runners' [n = 247], respectively). Measurements: The dependent variable was disability as assessed by the Health Assessment Questionnaire and separately validated in these participant cohorts. Covariates included age, sex, body mass index, comorbid conditions, education level, smoking history, alcohol intake, mean blood pressure, initial disability level, family history of arthritis, and radiologic evidence of osteoarthritis of the knee in a subsample. Results: Initially, the runners were leaner, reported joint symptoms less frequently, took fewer medications, had fewer medical problems, and had fewer instances of and less severity of disability, suggesting either that the average previous 12 years of running had improved health or that self-selection bias was present. After 8 years of longitudinal study, the differences in initial disability levels (0.026 compared with 0.079; P < 0.001) had steadily increased to 0.071 for runners compared with 0.242 for controls (P < 0.001). The difference was consistent for men and women. The rate of development of disability was several times lower in the runners' club members than in community controls; this difference persisted after adjusting for age, sex, body mass, baseline disability, smoking history, history of arthritis, or other comorbid conditions (slopes of progression of disability for the years 1984 to 1992, after adjusting for covariates: men in the runners' club, 0.004 [SE, 0.002]; community controls, 0.012 [SE, 0.002]; women in the runners' club, 0.009 [SE, 0.005]; community controls, 0.027 [SE, 0.004]; P < 0.002 for both sets of comparisons). In addition to differences in disability, there were significant differences in mortality between the runners' club members (1.49%) and community controls (7.09%) (P < 0.001). These differences remained significant after adjusting for age, sex, body mass, comorbid conditions, education level, smoking history, alcohol intake, and mean blood pressure (P < 0.002, conditional risk ratio for community controls compared with the runners, 4.27; 95% CI, 1.78 to 10.26). Conclusions: Older persons who engage in vigorous running and other aerobic activities have lower mortality and slower development of disability than do members of the general population. This association is probably related to increased aerobic activity, strength, fitness, and increased organ reserve rather than to an effect of postponed osteoarthritis development.

Original languageEnglish (US)
Pages (from-to)502-509
Number of pages8
JournalAnnals of Internal Medicine
Volume121
Issue number7
StatePublished - 1994
Externally publishedYes

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Longitudinal Studies
Smoking
History
Arthritis
Alcohols
Blood Pressure
Education
Mortality
Selection Bias
Knee Osteoarthritis
Health
Osteoarthritis
Body Mass Index
Joints
Odds Ratio
Prospective Studies
Population
Surveys and Questionnaires

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Fries, J. F., Singh, G., Morfeld, D., Hubert, H. B., Lane, N. E., & Brown, B. W. (1994). Running and the development of disability with age. Annals of Internal Medicine, 121(7), 502-509.

Running and the development of disability with age. / Fries, J. F.; Singh, G.; Morfeld, D.; Hubert, H. B.; Lane, Nancy E; Brown, B. W.

In: Annals of Internal Medicine, Vol. 121, No. 7, 1994, p. 502-509.

Research output: Contribution to journalArticle

Fries, JF, Singh, G, Morfeld, D, Hubert, HB, Lane, NE & Brown, BW 1994, 'Running and the development of disability with age', Annals of Internal Medicine, vol. 121, no. 7, pp. 502-509.
Fries JF, Singh G, Morfeld D, Hubert HB, Lane NE, Brown BW. Running and the development of disability with age. Annals of Internal Medicine. 1994;121(7):502-509.
Fries, J. F. ; Singh, G. ; Morfeld, D. ; Hubert, H. B. ; Lane, Nancy E ; Brown, B. W. / Running and the development of disability with age. In: Annals of Internal Medicine. 1994 ; Vol. 121, No. 7. pp. 502-509.
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abstract = "Objective: To determine, by longitudinal study, whether regular vigorous running activity is associated with accelerated, unchanged, or postponed development of disability with increasing age. Study design: 8-year prospective, longitudinal study with yearly assessments. Participants: 451 members of a runners' club and 330 community controls who were initially 50 to 72 years old (also characterized as 'ever-runners' [n = 534] and 'never-runners' [n = 247], respectively). Measurements: The dependent variable was disability as assessed by the Health Assessment Questionnaire and separately validated in these participant cohorts. Covariates included age, sex, body mass index, comorbid conditions, education level, smoking history, alcohol intake, mean blood pressure, initial disability level, family history of arthritis, and radiologic evidence of osteoarthritis of the knee in a subsample. Results: Initially, the runners were leaner, reported joint symptoms less frequently, took fewer medications, had fewer medical problems, and had fewer instances of and less severity of disability, suggesting either that the average previous 12 years of running had improved health or that self-selection bias was present. After 8 years of longitudinal study, the differences in initial disability levels (0.026 compared with 0.079; P < 0.001) had steadily increased to 0.071 for runners compared with 0.242 for controls (P < 0.001). The difference was consistent for men and women. The rate of development of disability was several times lower in the runners' club members than in community controls; this difference persisted after adjusting for age, sex, body mass, baseline disability, smoking history, history of arthritis, or other comorbid conditions (slopes of progression of disability for the years 1984 to 1992, after adjusting for covariates: men in the runners' club, 0.004 [SE, 0.002]; community controls, 0.012 [SE, 0.002]; women in the runners' club, 0.009 [SE, 0.005]; community controls, 0.027 [SE, 0.004]; P < 0.002 for both sets of comparisons). In addition to differences in disability, there were significant differences in mortality between the runners' club members (1.49{\%}) and community controls (7.09{\%}) (P < 0.001). These differences remained significant after adjusting for age, sex, body mass, comorbid conditions, education level, smoking history, alcohol intake, and mean blood pressure (P < 0.002, conditional risk ratio for community controls compared with the runners, 4.27; 95{\%} CI, 1.78 to 10.26). Conclusions: Older persons who engage in vigorous running and other aerobic activities have lower mortality and slower development of disability than do members of the general population. This association is probably related to increased aerobic activity, strength, fitness, and increased organ reserve rather than to an effect of postponed osteoarthritis development.",
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AU - Morfeld, D.

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AU - Lane, Nancy E

AU - Brown, B. W.

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N2 - Objective: To determine, by longitudinal study, whether regular vigorous running activity is associated with accelerated, unchanged, or postponed development of disability with increasing age. Study design: 8-year prospective, longitudinal study with yearly assessments. Participants: 451 members of a runners' club and 330 community controls who were initially 50 to 72 years old (also characterized as 'ever-runners' [n = 534] and 'never-runners' [n = 247], respectively). Measurements: The dependent variable was disability as assessed by the Health Assessment Questionnaire and separately validated in these participant cohorts. Covariates included age, sex, body mass index, comorbid conditions, education level, smoking history, alcohol intake, mean blood pressure, initial disability level, family history of arthritis, and radiologic evidence of osteoarthritis of the knee in a subsample. Results: Initially, the runners were leaner, reported joint symptoms less frequently, took fewer medications, had fewer medical problems, and had fewer instances of and less severity of disability, suggesting either that the average previous 12 years of running had improved health or that self-selection bias was present. After 8 years of longitudinal study, the differences in initial disability levels (0.026 compared with 0.079; P < 0.001) had steadily increased to 0.071 for runners compared with 0.242 for controls (P < 0.001). The difference was consistent for men and women. The rate of development of disability was several times lower in the runners' club members than in community controls; this difference persisted after adjusting for age, sex, body mass, baseline disability, smoking history, history of arthritis, or other comorbid conditions (slopes of progression of disability for the years 1984 to 1992, after adjusting for covariates: men in the runners' club, 0.004 [SE, 0.002]; community controls, 0.012 [SE, 0.002]; women in the runners' club, 0.009 [SE, 0.005]; community controls, 0.027 [SE, 0.004]; P < 0.002 for both sets of comparisons). In addition to differences in disability, there were significant differences in mortality between the runners' club members (1.49%) and community controls (7.09%) (P < 0.001). These differences remained significant after adjusting for age, sex, body mass, comorbid conditions, education level, smoking history, alcohol intake, and mean blood pressure (P < 0.002, conditional risk ratio for community controls compared with the runners, 4.27; 95% CI, 1.78 to 10.26). Conclusions: Older persons who engage in vigorous running and other aerobic activities have lower mortality and slower development of disability than do members of the general population. This association is probably related to increased aerobic activity, strength, fitness, and increased organ reserve rather than to an effect of postponed osteoarthritis development.

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