RRR-α-tocopheryl acetate supplementation at pharmacologic doses decreases low-density-lipoprotein oxidative susceptibility but not protein glycation in patients with diabetes mellitus

Cindy J. Fuller, Manisha Chandalia, Abhimanyu Garg, Scott M. Grundy, Ishwarlal Jialal

Research output: Contribution to journalArticle

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Abstract

Patients with diabetes mellitus have an increased risk of premature atherosclerosis, which may be due in part to increased oxx idizability of low-density lipoprotein (LDL). Numerous studies have shown that α-tocopherol can reduce the oxidative susceptibility of LDL in normoglycemic subjects: however, there are few studies in persons with diabetes. In addition, α- tocopherol may reduce the extent of protein glycation. Therefore, the objective of the present study was to assess the effect of RRR-α-tocopheryl acetate supplementation on LDL oxidizability and protein glycation in persons with diabetes without evidence of vascular disease. Twenty-eight persons with insulin-dependent diabetes mellitus (IDDM) and non-insulin-dependent diabetes mellitus (NIDDM) were randomly assigned to receive either placebo or 1632 mg (1200 IU) RRR-α-tocopherol/d, as tocopheryl acetate, for 8 wk. Plasma and LDL antioxidant concentrations and LDL oxidizability were assessed at both 0 and 8 wk. Plasma and LDL concentrations of α-tocopherol were significantly increased in the supplemented group only. Compared with the placebo group, the α-tocopherol-supplemented group had significant reductions in LDL oxidizability at 8 wk, as shown by the time-course curves of conjugated diene and lipid peroxide formation. Also, α-tocopherol supplementation produced a significant prolongation in the lag phases of both assays, which was evident in both the NIDDM and IDDM subgroups. However, there were no significant changes in glycated hemoglobin or in glycated plasma proteins after α- tocopherol supplementation. Thus, α-tocopherol supplementation may be beneficial in reducing LDL oxidizability in patients with diabetes.

Original languageEnglish (US)
Pages (from-to)753-759
Number of pages7
JournalAmerican Journal of Clinical Nutrition
Volume63
Issue number5
StatePublished - May 1996
Externally publishedYes

Fingerprint

glycation
Tocopherols
alpha-Tocopherol
low density lipoprotein
diabetes mellitus
LDL Lipoproteins
tocopherols
Diabetes Mellitus
acetates
dosage
Proteins
proteins
diabetes
insulin-dependent diabetes mellitus
Type 1 Diabetes Mellitus
noninsulin-dependent diabetes mellitus
Type 2 Diabetes Mellitus
placebos
Placebos
glycohemoglobin

Keywords

  • Diabetes
  • lipid peroxidation
  • low-density lipoprotein
  • vitamin E

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

RRR-α-tocopheryl acetate supplementation at pharmacologic doses decreases low-density-lipoprotein oxidative susceptibility but not protein glycation in patients with diabetes mellitus. / Fuller, Cindy J.; Chandalia, Manisha; Garg, Abhimanyu; Grundy, Scott M.; Jialal, Ishwarlal.

In: American Journal of Clinical Nutrition, Vol. 63, No. 5, 05.1996, p. 753-759.

Research output: Contribution to journalArticle

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