Rotationally oscillating drill (Ros-Drill©) for mouse ICSI without using mercury

Ali Fuat Ergenc, Ming Wen Li, Mehmet Toner, John D. Biggers, Kevin C K Lloyd, Nejat Olgac

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Intracytoplasmic sperm injection (ICSI) is an important assisted reproductive technology (ART). Due to deployment difficulties and low efficiency of the earlier (conventional) version of ICSI, especially in the mouse, a piezo-assisted ICSI technique had evolved as a popular ART methodology in recent years. An important and remaining problem with this technique, however, is that it requires small amounts of mercury to stabilize the pipette tip when piezoelectric force pulses are applied. To eliminate this problem we developed and tested a completely different and mercury-free technology, called the "Ros-Drill

Original languageEnglish (US)
Pages (from-to)1744-1751
Number of pages8
JournalMolecular Reproduction and Development
Issue number12
StatePublished - Dec 2008


  • Assisted reproduction
  • ICSI
  • Microinjection
  • Micromanipulation

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology
  • Cell Biology


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