RON, a tyrosine kinase receptor involved in tumor progression and metastasis

E. Ramsay Camp, Wenbiao Liu, Fan Fan, Anthony Yang, Ray Somcio, Lee M. Ellis

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

Tyrosine kinase receptors mediate many critical cellular functions that contribute to tumor progression and metastasis and thus are potential targets for molecular-based cancer therapy. As has been found for many receptor tyrosine kinases, RON (recepteur d'origine nantais) and its ligand, macrophage- stimulating protein, have recently been implicated in the progression and metastasis of tumors. In in vitro experiments using colon and breast cancer cell lines, overexpression of RON led to increased invasion and migration of cancer cells and prevented apoptosis and anoikis. In addition, transgenic mice engineered to overexpress RON in the lung epithelium developed multiple pulmonary tumors, suggesting a role for RON in tumorigenesis. In human cancer specimens, increased RON expression has been demonstrated in colon, breast, ovarian, and lung tumors. Therefore, therapies designed to inhibit RON activation may hinder critical tumor survival mechanisms and play a role in the treatment of advanced disease.

Original languageEnglish (US)
Pages (from-to)273-281
Number of pages9
JournalAnnals of Surgical Oncology
Volume12
Issue number4
DOIs
StatePublished - Apr 2005
Externally publishedYes

Fingerprint

Receptor Protein-Tyrosine Kinases
Neoplasm Metastasis
Neoplasms
Lung
Anoikis
RON protein
Colonic Neoplasms
Transgenic Mice
Cell Movement
Colon
Carcinogenesis
Breast
Epithelium
Apoptosis
Breast Neoplasms
Ligands
Cell Line
Survival
Therapeutics

Keywords

  • Cancer
  • Macrophage-stimulating protein
  • RON
  • Tyrosine kinase receptor

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Camp, E. R., Liu, W., Fan, F., Yang, A., Somcio, R., & Ellis, L. M. (2005). RON, a tyrosine kinase receptor involved in tumor progression and metastasis. Annals of Surgical Oncology, 12(4), 273-281. https://doi.org/10.1245/ASO.2005.08.013

RON, a tyrosine kinase receptor involved in tumor progression and metastasis. / Camp, E. Ramsay; Liu, Wenbiao; Fan, Fan; Yang, Anthony; Somcio, Ray; Ellis, Lee M.

In: Annals of Surgical Oncology, Vol. 12, No. 4, 04.2005, p. 273-281.

Research output: Contribution to journalArticle

Camp, ER, Liu, W, Fan, F, Yang, A, Somcio, R & Ellis, LM 2005, 'RON, a tyrosine kinase receptor involved in tumor progression and metastasis', Annals of Surgical Oncology, vol. 12, no. 4, pp. 273-281. https://doi.org/10.1245/ASO.2005.08.013
Camp, E. Ramsay ; Liu, Wenbiao ; Fan, Fan ; Yang, Anthony ; Somcio, Ray ; Ellis, Lee M. / RON, a tyrosine kinase receptor involved in tumor progression and metastasis. In: Annals of Surgical Oncology. 2005 ; Vol. 12, No. 4. pp. 273-281.
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