Role played by P2X and P2Y receptors in evoking the muscle chemoreflex

Shawn G. Hayes, Jennifer L. McCord, Marc P Kaufman

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

The role played by purinergic 2Y receptors in evoking the muscle chemoreflex is not well defined. To shed light on this issue, we compared the pressor responses with popliteal arterial injection of UTP (1 mg/kg), a selective P2Y agonist, with those to popliteal arterial injection of ATP (1 mg/kg), a P2X and P2Y agonist, and to α,β-methylene ATP (50 μg/kg), a selective P2X1 and P2X3 agonist, in decerebrate unanesthetized cats. We found that injection of ATP and α,β-methylene ATP increased mean arterial pressure by 19 ± 2 and 15 ± 4 mmHg, whereas UTP had no affect on arterial pressure. In addition, the pressor responses to injection of ATP and α,β-methylene ATP were abolished by section of the sciatic nerve, demonstrating that they were reflex in origin. We conclude that P2Y receptors on thin fiber muscle afferents play no role in evoking the muscle chemoreflex.

Original languageEnglish (US)
Pages (from-to)538-541
Number of pages4
JournalJournal of Applied Physiology
Volume104
Issue number2
DOIs
StatePublished - Feb 2008
Externally publishedYes

Keywords

  • Autonomic nervous system
  • Cats
  • Exercise
  • Groups III and IV muscle afferents
  • Neural control of circulation
  • Phrenic nerve activity

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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