Role of triglyceride-rich lipoproteins in renal injury

Kit Fai Ng, Hnin Hnin Aung, John C Rutledge

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

Dyslipidemia is implicated as a risk factor for the development of atherosclerosis. Specifically triglyceride-rich lipoproteins and their lipolysis products are shown to be proinflammatory and proapoptosis in both in vivo and in vitro studies with endothelium. However, the role of triglyceride-rich lipoproteins in the progression of kidney diseases is not clear. Epidemiology studies demonstrated a correlation between renal disease and blood lipids. Recent evidence suggests that the mechanism may involve cellular uptake of lipid and de novo lipogenesis. Further studies are needed to establish the relevance of these mechanistic studies in human pathophysiology.

Original languageEnglish (US)
Title of host publicationDiabetes and the Kidney
PublisherS. Karger AG
Pages165-171
Number of pages7
Volume170
ISBN (Print)9783805597432, 9783805597425
DOIs
StatePublished - Jun 8 2011

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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    Ng, K. F., Aung, H. H., & Rutledge, J. C. (2011). Role of triglyceride-rich lipoproteins in renal injury. In Diabetes and the Kidney (Vol. 170, pp. 165-171). S. Karger AG. https://doi.org/10.1159/000325654