Abstract
Dyslipidemia is implicated as a risk factor for the development of atherosclerosis. Specifically triglyceride-rich lipoproteins and their lipolysis products are shown to be proinflammatory and proapoptosis in both in vivo and in vitro studies with endothelium. However, the role of triglyceride-rich lipoproteins in the progression of kidney diseases is not clear. Epidemiology studies demonstrated a correlation between renal disease and blood lipids. Recent evidence suggests that the mechanism may involve cellular uptake of lipid and de novo lipogenesis. Further studies are needed to establish the relevance of these mechanistic studies in human pathophysiology.
| Original language | English (US) |
|---|---|
| Title of host publication | Diabetes and the Kidney |
| Publisher | S. Karger AG |
| Pages | 165-171 |
| Number of pages | 7 |
| Volume | 170 |
| ISBN (Print) | 9783805597432, 9783805597425 |
| DOIs | |
| State | Published - Jun 8 2011 |
ASJC Scopus subject areas
- Medicine(all)
- Biochemistry, Genetics and Molecular Biology(all)
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Cite this
Ng, K. F., Aung, H. H., & Rutledge, J. C. (2011). Role of triglyceride-rich lipoproteins in renal injury. In Diabetes and the Kidney (Vol. 170, pp. 165-171). S. Karger AG. https://doi.org/10.1159/000325654