Abstract
Dyslipidemia is implicated as a risk factor for the development of atherosclerosis. Specifically triglyceride-rich lipoproteins and their lipolysis products are shown to be proinflammatory and proapoptosis in both in vivo and in vitro studies with endothelium. However, the role of triglyceride-rich lipoproteins in the progression of kidney diseases is not clear. Epidemiology studies demonstrated a correlation between renal disease and blood lipids. Recent evidence suggests that the mechanism may involve cellular uptake of lipid and de novo lipogenesis. Further studies are needed to establish the relevance of these mechanistic studies in human pathophysiology.
| Original language | English (US) |
|---|---|
| Title of host publication | Diabetes and the Kidney |
| Publisher | S. Karger AG |
| Pages | 165-171 |
| Number of pages | 7 |
| Volume | 170 |
| ISBN (Print) | 9783805597432, 9783805597425 |
| DOIs | |
| State | Published - Jun 8 2011 |
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ASJC Scopus subject areas
- Medicine(all)
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Role of triglyceride-rich lipoproteins in renal injury. / Ng, Kit Fai; Aung, Hnin Hnin; Rutledge, John C.
Diabetes and the Kidney. Vol. 170 S. Karger AG, 2011. p. 165-171.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Role of triglyceride-rich lipoproteins in renal injury
AU - Ng, Kit Fai
AU - Aung, Hnin Hnin
AU - Rutledge, John C
PY - 2011/6/8
Y1 - 2011/6/8
N2 - Dyslipidemia is implicated as a risk factor for the development of atherosclerosis. Specifically triglyceride-rich lipoproteins and their lipolysis products are shown to be proinflammatory and proapoptosis in both in vivo and in vitro studies with endothelium. However, the role of triglyceride-rich lipoproteins in the progression of kidney diseases is not clear. Epidemiology studies demonstrated a correlation between renal disease and blood lipids. Recent evidence suggests that the mechanism may involve cellular uptake of lipid and de novo lipogenesis. Further studies are needed to establish the relevance of these mechanistic studies in human pathophysiology.
AB - Dyslipidemia is implicated as a risk factor for the development of atherosclerosis. Specifically triglyceride-rich lipoproteins and their lipolysis products are shown to be proinflammatory and proapoptosis in both in vivo and in vitro studies with endothelium. However, the role of triglyceride-rich lipoproteins in the progression of kidney diseases is not clear. Epidemiology studies demonstrated a correlation between renal disease and blood lipids. Recent evidence suggests that the mechanism may involve cellular uptake of lipid and de novo lipogenesis. Further studies are needed to establish the relevance of these mechanistic studies in human pathophysiology.
UR - http://www.scopus.com/inward/record.url?scp=84925938796&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84925938796&partnerID=8YFLogxK
U2 - 10.1159/000325654
DO - 10.1159/000325654
M3 - Chapter
C2 - 21659769
AN - SCOPUS:84925938796
SN - 9783805597432
SN - 9783805597425
VL - 170
SP - 165
EP - 171
BT - Diabetes and the Kidney
PB - S. Karger AG
ER -