Role of the parabrachial nuclei in the airway dilation evoked by the Hering-Breuer reflex

Ann M. Motekaitis; Irene C. Solomon; Marc P Kaufman

doi:10.1016/0006-8993(94)01371-N

Role of the parabrachial nuclei in the airway dilation evoked by the Hering-Breuer reflex

Ann M. Motekaitis, Irene C. Solomon, Marc P Kaufman

Cardiovascular Medicine

Research output: Contribution to journal › Article

6 Scopus citations

Abstract

We tested the hypothesis that blockade of glutamatergic receptors in the parabrachial nucleus (PBN) of chloralose-anesthetized cats attenuated the reflex airway dilation evoked by activation of pulmonary stretch receptors. Unilateral microinjection of kynurenic acid (50 nl, 100 mM) into the PBN reversibly attenuated the reflex relaxation of the trachealis muscle in 7 cats. These findings suggest that the PBN is part of the central pathway mediating the airway dilation component of the Hering-Breuer reflex.

Original language	English (US)
Pages (from-to)	314-316
Number of pages	3
Journal	Brain Research
Volume	671
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(94)01371-N
State	Published - Feb 13 1995

Fingerprint

Keywords

Airway smooth muscle
Autonomic nervous system
Pneumotaxic center

ASJC Scopus subject areas

Developmental Biology
Molecular Biology
Clinical Neurology
Neuroscience(all)

Cite this

Motekaitis, A. M., Solomon, I. C., & Kaufman, M. P. (1995). Role of the parabrachial nuclei in the airway dilation evoked by the Hering-Breuer reflex. Brain Research, 671(2), 314-316. https://doi.org/10.1016/0006-8993(94)01371-N

@article{e97107fdb2cf4772a4b996a022b7ff2f,

title = "Role of the parabrachial nuclei in the airway dilation evoked by the Hering-Breuer reflex",

abstract = "We tested the hypothesis that blockade of glutamatergic receptors in the parabrachial nucleus (PBN) of chloralose-anesthetized cats attenuated the reflex airway dilation evoked by activation of pulmonary stretch receptors. Unilateral microinjection of kynurenic acid (50 nl, 100 mM) into the PBN reversibly attenuated the reflex relaxation of the trachealis muscle in 7 cats. These findings suggest that the PBN is part of the central pathway mediating the airway dilation component of the Hering-Breuer reflex.",

keywords = "Airway smooth muscle, Autonomic nervous system, Pneumotaxic center",

author = "Motekaitis, {Ann M.} and Solomon, {Irene C.} and Kaufman, {Marc P}",

year = "1995",

month = feb

day = "13",

doi = "10.1016/0006-8993(94)01371-N",

language = "English (US)",

volume = "671",

pages = "314--316",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier",

number = "2",

}

TY - JOUR

T1 - Role of the parabrachial nuclei in the airway dilation evoked by the Hering-Breuer reflex

AU - Motekaitis, Ann M.

AU - Solomon, Irene C.

AU - Kaufman, Marc P

PY - 1995/2/13

Y1 - 1995/2/13

N2 - We tested the hypothesis that blockade of glutamatergic receptors in the parabrachial nucleus (PBN) of chloralose-anesthetized cats attenuated the reflex airway dilation evoked by activation of pulmonary stretch receptors. Unilateral microinjection of kynurenic acid (50 nl, 100 mM) into the PBN reversibly attenuated the reflex relaxation of the trachealis muscle in 7 cats. These findings suggest that the PBN is part of the central pathway mediating the airway dilation component of the Hering-Breuer reflex.

AB - We tested the hypothesis that blockade of glutamatergic receptors in the parabrachial nucleus (PBN) of chloralose-anesthetized cats attenuated the reflex airway dilation evoked by activation of pulmonary stretch receptors. Unilateral microinjection of kynurenic acid (50 nl, 100 mM) into the PBN reversibly attenuated the reflex relaxation of the trachealis muscle in 7 cats. These findings suggest that the PBN is part of the central pathway mediating the airway dilation component of the Hering-Breuer reflex.

KW - Airway smooth muscle

KW - Autonomic nervous system

KW - Pneumotaxic center

UR - http://www.scopus.com/inward/record.url?scp=0028889853&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028889853&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(94)01371-N

DO - 10.1016/0006-8993(94)01371-N

M3 - Article

C2 - 7743221

AN - SCOPUS:0028889853

VL - 671

SP - 314

EP - 316

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 2

ER -

Access to Document

10.1016/0006-8993(94)01371-N