Role of the parabrachial nuclei in the airway dilation evoked by the Hering-Breuer reflex

Ann M. Motekaitis, Irene C. Solomon, Marc P Kaufman

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

We tested the hypothesis that blockade of glutamatergic receptors in the parabrachial nucleus (PBN) of chloralose-anesthetized cats attenuated the reflex airway dilation evoked by activation of pulmonary stretch receptors. Unilateral microinjection of kynurenic acid (50 nl, 100 mM) into the PBN reversibly attenuated the reflex relaxation of the trachealis muscle in 7 cats. These findings suggest that the PBN is part of the central pathway mediating the airway dilation component of the Hering-Breuer reflex.

Original languageEnglish (US)
Pages (from-to)314-316
Number of pages3
JournalBrain Research
Volume671
Issue number2
DOIs
StatePublished - Feb 13 1995

Keywords

  • Airway smooth muscle
  • Autonomic nervous system
  • Pneumotaxic center

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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