Abstract
We tested the hypothesis that blockade of glutamatergic receptors in the parabrachial nucleus (PBN) of chloralose-anesthetized cats attenuated the reflex airway dilation evoked by activation of pulmonary stretch receptors. Unilateral microinjection of kynurenic acid (50 nl, 100 mM) into the PBN reversibly attenuated the reflex relaxation of the trachealis muscle in 7 cats. These findings suggest that the PBN is part of the central pathway mediating the airway dilation component of the Hering-Breuer reflex.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 314-316 |
| Number of pages | 3 |
| Journal | Brain Research |
| Volume | 671 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 13 1995 |
Keywords
- Airway smooth muscle
- Autonomic nervous system
- Pneumotaxic center
ASJC Scopus subject areas
- Developmental Biology
- Molecular Biology
- Clinical Neurology
- Neuroscience(all)
Fingerprint Dive into the research topics of 'Role of the parabrachial nuclei in the airway dilation evoked by the Hering-Breuer reflex'. Together they form a unique fingerprint.
Cite this
Motekaitis, A. M., Solomon, I. C., & Kaufman, M. P. (1995). Role of the parabrachial nuclei in the airway dilation evoked by the Hering-Breuer reflex. Brain Research, 671(2), 314-316. https://doi.org/10.1016/0006-8993(94)01371-N