Role of the hemostatic system on sickle cell disease pathophysiology and potential therapeutics

Zahra Pakbaz, Theodore Wun

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Recent studies suggest that sickle cell disease (SCD) is a hypercoagulable state contributing to vaso-occlusive events in the microcirculation, resulting in acute and chronic sickle cell-related organ damage. In this article, we review the existing evidence for contribution of hemostatic system perturbation to SCD pathophysiology. We also review the data showing increased risk of thromboembolic events, particularly newer information on the incidence of venous thromboembolism. Finally, the potential role of platelet inhibitors and anticoagulants in SCD is briefly reviewed.

Original languageEnglish (US)
Pages (from-to)355-374
Number of pages20
JournalHematology/Oncology Clinics of North America
Volume28
Issue number2
DOIs
StatePublished - Apr 2014

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Keywords

  • Anti-platelets
  • Anticoagulants
  • Hypercoagulable
  • Sickle cell
  • Thromboembolism

ASJC Scopus subject areas

  • Oncology
  • Hematology
  • Medicine(all)

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