Abstract
Recent studies suggest that sickle cell disease (SCD) is a hypercoagulable state contributing to vaso-occlusive events in the microcirculation, resulting in acute and chronic sickle cell-related organ damage. In this article, we review the existing evidence for contribution of hemostatic system perturbation to SCD pathophysiology. We also review the data showing increased risk of thromboembolic events, particularly newer information on the incidence of venous thromboembolism. Finally, the potential role of platelet inhibitors and anticoagulants in SCD is briefly reviewed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 355-374 |
| Number of pages | 20 |
| Journal | Hematology/Oncology Clinics of North America |
| Volume | 28 |
| Issue number | 2 |
| DOIs | |
| State | Published - Apr 2014 |
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Keywords
- Anti-platelets
- Anticoagulants
- Hypercoagulable
- Sickle cell
- Thromboembolism
ASJC Scopus subject areas
- Oncology
- Hematology
- Medicine(all)
Cite this
Role of the hemostatic system on sickle cell disease pathophysiology and potential therapeutics. / Pakbaz, Zahra; Wun, Theodore.
In: Hematology/Oncology Clinics of North America, Vol. 28, No. 2, 04.2014, p. 355-374.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Role of the hemostatic system on sickle cell disease pathophysiology and potential therapeutics
AU - Pakbaz, Zahra
AU - Wun, Theodore
PY - 2014/4
Y1 - 2014/4
N2 - Recent studies suggest that sickle cell disease (SCD) is a hypercoagulable state contributing to vaso-occlusive events in the microcirculation, resulting in acute and chronic sickle cell-related organ damage. In this article, we review the existing evidence for contribution of hemostatic system perturbation to SCD pathophysiology. We also review the data showing increased risk of thromboembolic events, particularly newer information on the incidence of venous thromboembolism. Finally, the potential role of platelet inhibitors and anticoagulants in SCD is briefly reviewed.
AB - Recent studies suggest that sickle cell disease (SCD) is a hypercoagulable state contributing to vaso-occlusive events in the microcirculation, resulting in acute and chronic sickle cell-related organ damage. In this article, we review the existing evidence for contribution of hemostatic system perturbation to SCD pathophysiology. We also review the data showing increased risk of thromboembolic events, particularly newer information on the incidence of venous thromboembolism. Finally, the potential role of platelet inhibitors and anticoagulants in SCD is briefly reviewed.
KW - Anti-platelets
KW - Anticoagulants
KW - Hypercoagulable
KW - Sickle cell
KW - Thromboembolism
UR - http://www.scopus.com/inward/record.url?scp=84896733894&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84896733894&partnerID=8YFLogxK
U2 - 10.1016/j.hoc.2013.11.011
DO - 10.1016/j.hoc.2013.11.011
M3 - Article
C2 - 24589271
AN - SCOPUS:84896733894
VL - 28
SP - 355
EP - 374
JO - Hematology/Oncology Clinics of North America
JF - Hematology/Oncology Clinics of North America
SN - 0889-8588
IS - 2
ER -