Role of soluble epoxide hydrolase phosphatase activity in the metabolism of lysophosphatidic acids

Christophe Morisseau, Nils Helge Schebb, Hua Dong, Arzu Ulu, Pavel A. Aronov, Bruce D. Hammock

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

The EPXH2 gene encodes for the soluble epoxide hydrolase (sEH), which has two distinct enzyme activities: epoxide hydrolase (Cterm-EH) and phosphatase (Nterm-phos). The Cterm-EH is involved in the metabolism of epoxides from arachidonic acid and other unsaturated fatty acids, endogenous chemical mediators that play important roles in blood pressure regulation, cell growth, inflammation and pain. While recent findings suggested complementary biological roles for Nterm-phos, its mode of action is not well understood. Herein, we demonstrate that lysophosphatidic acids are excellent substrates for Nterm-phos. We also showed that sEH phosphatase activity represents a significant (20-60%) part of LPA cellular hydrolysis, especially in the cytosol. This possible role of sEH on LPA hydrolysis could explain some of the biology previously associated with the Nterm-phos. These findings also underline possible cellular mechanisms by which both activities of sEH (EH and phosphatase) may have complementary or opposite roles.

Original languageEnglish (US)
Pages (from-to)796-800
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume419
Issue number4
DOIs
StatePublished - Mar 23 2012

Keywords

  • Lysophosphatidic acid
  • Phosphatase
  • Soluble epoxide hydrolase

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Molecular Biology

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