Role of small intestine in caloric compensations to oil premeals in rats

J. H. Meyer, M. Hlinka, A. Khatibi, Helen E Raybould, P. Tso

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

We postulated that dose-responsive satiety after oil premeals varies with the number of gut sensors stimulated by lipolytic products along intestine. These experiments in fasted rats on satiety after oil premeals were performed to 1) determine whether satiety was induced by lipolytic products but not triglycerides; 2) confirm that oil empties from the stomach at rates that vary with oil loads; 3) ascertain that increasing rates of oil entry into duodenum extend the length of gut contacted by lipolytic products; and 4)judge whether length of gut contacted correlated with dose-responsive satieties to dietary oils. 5) Using specific antagonists, we attempted to define how satiety was signalled by gut sensors. Timing and degrees of satiety did not correlate with timing and extent of gastric distensions but, rather, with the timing and extent of spread of lipolytic products along small bowel. Satiety after the highest premeal load of oil was blocked by Pluronic L-81, an inhibitor of intestinal secretion of apolipoprotein A-IV, but was unaffected by MK-329 (a specific antagonist of cholecystokinin) or by capsaicin blockade of chemosensory nerves.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume275
Issue number4 44-4
StatePublished - Oct 1998
Externally publishedYes

Fingerprint

Small Intestine
Oils
Stomach
Devazepide
Unsaturated Dietary Fats
Intestinal Secretions
Poloxamer
Nerve Block
Capsaicin
Cholecystokinin
Duodenum
Intestines
Triglycerides

Keywords

  • Caloric adjustments
  • Temporality

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Role of small intestine in caloric compensations to oil premeals in rats. / Meyer, J. H.; Hlinka, M.; Khatibi, A.; Raybould, Helen E; Tso, P.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 275, No. 4 44-4, 10.1998.

Research output: Contribution to journalArticle

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