Role of sebaceous glands in inflammatory dermatoses

Vivian Y. Shi, Michael Leo, Lauren Hassoun, Dev S. Chahal, Howard I. Maibach, Raja K Sivamani

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Skin is an important interface between the host and its environment. Inflammatory dermatoses often have disrupted skin barrier function, rendering patients more susceptible to allergenic triggers leading to an exaggerated immune response. The skin surface lipid film, an important component of the skin barrier, comprises a mixture of keratinocyte and sebaceous gland-derived lipids. Recent evidence demonstrated that defective keratinocyte lipid synthesis predisposes for the development of atopic dermatitis. However, the important role of sebaceous gland-derived lipids in skin inflammatory diseases may be underrecognized. This overview focuses on the importance of the contribution of sebaceous glands to barrier function. Sebaceous gland alteration may play a role in the pathogenesis of common skin diseases including acne vulgaris, atopic dermatitis, psoriasis, rosacea, and seborrheic dermatitis.

Original languageEnglish (US)
Pages (from-to)856-863
Number of pages8
JournalJournal of the American Academy of Dermatology
Volume73
Issue number5
DOIs
StatePublished - Nov 1 2015

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Keywords

  • acne
  • atopic dermatitis
  • eczema
  • psoriasis
  • rosacea
  • sebocytes
  • seborrheic dermatitis
  • sebum

ASJC Scopus subject areas

  • Dermatology

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