Role of protein synthesis in the replication of the killer virus of yeast

Michael J Leibowitz

doi:10.1007/BF00365709

Role of protein synthesis in the replication of the killer virus of yeast

Michael J Leibowitz

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Growth of yeast in the presence of the protein synthesis inhibitors cycloheximide and cryptopleurine results in elimination ("curing") of the cytoplasmically-inherited killer virus. Yeast mutants with ribosomal subunits resistant to the translational effects of one of these antibiotics are specifically resistant to curing by that antibiotic, indicating that these substances act on the virus by their effect on protein synthesis.

Original language	English (US)
Pages (from-to)	161-163
Number of pages	3
Journal	Current Genetics
Volume	5
Issue number	2
DOIs	https://doi.org/10.1007/BF00365709
State	Published - Jul 1982
Externally published	Yes

Keywords

Cryptopleurine
Cycloheximide
Killer virus

ASJC Scopus subject areas

Genetics

Access to Document

10.1007/BF00365709

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title = "Role of protein synthesis in the replication of the killer virus of yeast",

abstract = "Growth of yeast in the presence of the protein synthesis inhibitors cycloheximide and cryptopleurine results in elimination ({"}curing{"}) of the cytoplasmically-inherited killer virus. Yeast mutants with ribosomal subunits resistant to the translational effects of one of these antibiotics are specifically resistant to curing by that antibiotic, indicating that these substances act on the virus by their effect on protein synthesis.",

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AB - Growth of yeast in the presence of the protein synthesis inhibitors cycloheximide and cryptopleurine results in elimination ("curing") of the cytoplasmically-inherited killer virus. Yeast mutants with ribosomal subunits resistant to the translational effects of one of these antibiotics are specifically resistant to curing by that antibiotic, indicating that these substances act on the virus by their effect on protein synthesis.

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