Role of plasma and serum proteases in the degradation of elastin

Nadia Romero, Donald Tinker, Dallas Hyde, Robert B. Rucker

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Accelerated proteolysis of tropoelastin and elastin occurs in the major arteries of chicks fed copper-deficient diets. Signs of elastin degradation are not obvious in normal arteries of copper-supplemented chicks. It is proposed that the sources of proteases that effect elastin degradation are from plasma and serum. Both calcium-dependent proteases and kallikrein were effective in degrading tropoelastin and partially crosslinked insoluble elastin into peptides similar to those detected in aortic extracts from copper-deficient chicks. As dietary copper deficiency progresses it is also possible to detect elastin peptides in plasma.

Original languageEnglish (US)
Pages (from-to)161-168
Number of pages8
JournalArchives of Biochemistry and Biophysics
Volume244
Issue number1
DOIs
StatePublished - 1986

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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