Role of oxygen in limiting respiration in the in situ myocardium

Ulrike Kreutzer, Yousry Mekhamer, Tuan Khanh Tran, Thomas Jue

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

1H NMR has now detected the proximal histidyl N(δ)H myoglobin (Mb) signal from the myocardium in situ. Upon ligation of the left anterior descending coronary artery in the rat myocardium, the deoxy Mb signal appears at 78 ppm During dopamine infusion at up to 80 μg/kg/min, the heart rate pressure product (RPP) increases by a factor of 2, the phosphocreatine (PCr) decreases by 17%, and the ratio of the change in inorganic phosphate over PCr (ΔP(i)/PCr) increases by 0.2. However, no deoxy myoglobin signal is detected. Oxygen availability does not appear to limit oxygen consumption nor oxidative phosphorylation under dopamine enhanced work state in myocardium.

Original languageEnglish (US)
Pages (from-to)2651-2655
Number of pages5
JournalJournal of Molecular and Cellular Cardiology
Volume30
Issue number12
DOIs
StatePublished - Dec 1998

Keywords

  • Myocardium
  • Myoglobin
  • NMR
  • Oxidative phosphorylation
  • Respiration

ASJC Scopus subject areas

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine

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