Abstract
1H NMR has now detected the proximal histidyl N(δ)H myoglobin (Mb) signal from the myocardium in situ. Upon ligation of the left anterior descending coronary artery in the rat myocardium, the deoxy Mb signal appears at 78 ppm During dopamine infusion at up to 80 μg/kg/min, the heart rate pressure product (RPP) increases by a factor of 2, the phosphocreatine (PCr) decreases by 17%, and the ratio of the change in inorganic phosphate over PCr (ΔP(i)/PCr) increases by 0.2. However, no deoxy myoglobin signal is detected. Oxygen availability does not appear to limit oxygen consumption nor oxidative phosphorylation under dopamine enhanced work state in myocardium.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2651-2655 |
| Number of pages | 5 |
| Journal | Journal of Molecular and Cellular Cardiology |
| Volume | 30 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 1998 |
Keywords
- Myocardium
- Myoglobin
- NMR
- Oxidative phosphorylation
- Respiration
ASJC Scopus subject areas
- Molecular Biology
- Cardiology and Cardiovascular Medicine
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Kreutzer, U., Mekhamer, Y., Tran, T. K., & Jue, T. (1998). Role of oxygen in limiting respiration in the in situ myocardium. Journal of Molecular and Cellular Cardiology, 30(12), 2651-2655. https://doi.org/10.1006/jmcc.1998.0823