Role of NO and other vascular mediators in the etiopathogenesis of necrotizing enterocolitis

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The etio-pathogenesis of necrotizing enterocolitis (NEC) is complex and multifactorial. Decades of research have not identified a definite etiology. Prematurity, enteral feeding, intestinal hypoxia/ischemia, inflammation and an abnormal microbiome are potential risk factors for developing this multisystem illness. Lack of specific diagnostic and prognostic markers adds to the challenges faced in managing NEC. Vascular mediators such as Nitric oxide (NO), catecholamines and endothelin (ET) regulate neonatal intestinal vascular resistance and may influence the pathophysiology of NEC. Neonatal morbidities, medications, transfusions, an altered microbiome and breast milk feeds may influence the vasculature in various ways. Better understanding of these mediators and their role in regulation of intestinal microcirculation and pathogenesis of NEC will assist in identifying strategies in prevention and management of this devastating illness.

Original languageEnglish (US)
Pages (from-to)9-28
Number of pages20
JournalFrontiers in Bioscience - Scholar
Volume11
Issue number1
DOIs
StatePublished - Mar 1 2019

Keywords

  • Endothelin
  • Mesenteric Circulation
  • Necrotizing Enterocolitis
  • Neonatal
  • Nitric Oxide
  • Review
  • Vasoconstriction

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Fingerprint Dive into the research topics of 'Role of NO and other vascular mediators in the etiopathogenesis of necrotizing enterocolitis'. Together they form a unique fingerprint.

Cite this