Role of nerve growth factor in rantes expression by keratinocytes

Siba P Raychaudhuri, E. M. Farber, S. K. Raychaudhuri

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

A role of neurogenic inflammation induced by the neuropeptides and nerve growth factor (NGF) has been attributed to the pathogenesis of several cutaneous disorders such as psoriasis, wound healing and eczematous dermatitis. The underlying mechanisms of the inflammatory process induced by NGF are not clearly established. This study explored whether NGF influences the inflammatory process by inducing chemokines. The effects of NGF were investigated on induction of 2 important chemokines, interleukin-8 and RANTES, which are known to be upregulated in the keratinocytes of various inflammatory conditions. NGF significantly increased RANTES production by the keratinocytes (p<0.001, 2-tailed Student's t-test). Induction of RANTES expression in the keratinocytes by NGF provides further insight regarding the role of NGF-NGF receptor system in cutaneous inflammatory conditions.

Original languageEnglish (US)
Pages (from-to)247-250
Number of pages4
JournalActa Dermato-Venereologica
Volume80
Issue number4
StatePublished - 2000
Externally publishedYes

Keywords

  • Chemokines
  • Cutaneous inflammation
  • Keratinocytes
  • NGF
  • RANTES

ASJC Scopus subject areas

  • Dermatology

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