Role of Na-K pump potassium regulation and IPSPs in seizures and spreading depression in immature rabbit hippocampal slices

M. M. Haglund, Philip A Schwartzkroin

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129 Citations (Scopus)

Abstract

Using the immature (8-12 days postnatal) rabbit hippocampal slice preparation, we investigated regional extracellular potassium concentration ([K+)(o)) changes that occur during spontaneous and evoked spreading depression (SD) episodes. We report here a difference between the CA1 and CA3 cell populations in the immature hippocampus with regard to 1) resting [K+](o), 2) magnitude of the [K+](o) change during seizurelike events and SDs, and 3) susceptibility to SD episodes. Experiments were also performed to elucidate the roles that the Na-K pump and synaptic inhibition play in controlling SD onset, duration, and recovery. We demonstrated a major role for potassium regulation by the Na-K pump and a lesser modulatory role for inhibitory postsynaptic potentials (IPSPs) in preventing SD in the CA3 region.

Original languageEnglish (US)
Pages (from-to)225-239
Number of pages15
JournalJournal of Neurophysiology
Volume63
Issue number2
StatePublished - 1990
Externally publishedYes

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Sodium-Potassium-Exchanging ATPase
Inhibitory Postsynaptic Potentials
Potassium
Seizures
Rabbits
Hippocampus
Population

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)

Cite this

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AB - Using the immature (8-12 days postnatal) rabbit hippocampal slice preparation, we investigated regional extracellular potassium concentration ([K+)(o)) changes that occur during spontaneous and evoked spreading depression (SD) episodes. We report here a difference between the CA1 and CA3 cell populations in the immature hippocampus with regard to 1) resting [K+](o), 2) magnitude of the [K+](o) change during seizurelike events and SDs, and 3) susceptibility to SD episodes. Experiments were also performed to elucidate the roles that the Na-K pump and synaptic inhibition play in controlling SD onset, duration, and recovery. We demonstrated a major role for potassium regulation by the Na-K pump and a lesser modulatory role for inhibitory postsynaptic potentials (IPSPs) in preventing SD in the CA3 region.

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