Role of lymphocytes in macrophage-induced killing of Coccidioides immitis in vitro

L. Beaman, E. Benjamini, Demosthenes Pappagianis

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Peritoneal macrophages from normal mice phagocytized arthroconidia and endospores of Coccidioides immitis without affecting the viability of the spores within 4 h after infection. In contrast, macrophages, when infected in the presence of lymphocytes from immune mice, significantly reduced the viability of phagocytized endospores and arthroconidia. The inability of macrophages from normal mice to kill C. immitis may in part be explained by the observation that C. immitis appeared to inhibit fusion of the phagosomes containing fungal spores with the lysosomes within the macrophages. However, fusion of phagosomes containing spores and lysosomes was observed in macrophages infected in the presence of lymphocytes from immune mice.

Original languageEnglish (US)
Pages (from-to)347-353
Number of pages7
JournalInfection and Immunity
Volume34
Issue number2
StatePublished - 1981

Fingerprint

Coccidioides
Macrophages
Lymphocytes
Phagosomes
Lysosomes
Spores
Fungal Spores
Peritoneal Macrophages
In Vitro Techniques
Infection

ASJC Scopus subject areas

  • Immunology

Cite this

Role of lymphocytes in macrophage-induced killing of Coccidioides immitis in vitro. / Beaman, L.; Benjamini, E.; Pappagianis, Demosthenes.

In: Infection and Immunity, Vol. 34, No. 2, 1981, p. 347-353.

Research output: Contribution to journalArticle

@article{ec165b5e24134bebb87838f1add3527c,
title = "Role of lymphocytes in macrophage-induced killing of Coccidioides immitis in vitro",
abstract = "Peritoneal macrophages from normal mice phagocytized arthroconidia and endospores of Coccidioides immitis without affecting the viability of the spores within 4 h after infection. In contrast, macrophages, when infected in the presence of lymphocytes from immune mice, significantly reduced the viability of phagocytized endospores and arthroconidia. The inability of macrophages from normal mice to kill C. immitis may in part be explained by the observation that C. immitis appeared to inhibit fusion of the phagosomes containing fungal spores with the lysosomes within the macrophages. However, fusion of phagosomes containing spores and lysosomes was observed in macrophages infected in the presence of lymphocytes from immune mice.",
author = "L. Beaman and E. Benjamini and Demosthenes Pappagianis",
year = "1981",
language = "English (US)",
volume = "34",
pages = "347--353",
journal = "Infection and Immunity",
issn = "0019-9567",
publisher = "American Society for Microbiology",
number = "2",

}

TY - JOUR

T1 - Role of lymphocytes in macrophage-induced killing of Coccidioides immitis in vitro

AU - Beaman, L.

AU - Benjamini, E.

AU - Pappagianis, Demosthenes

PY - 1981

Y1 - 1981

N2 - Peritoneal macrophages from normal mice phagocytized arthroconidia and endospores of Coccidioides immitis without affecting the viability of the spores within 4 h after infection. In contrast, macrophages, when infected in the presence of lymphocytes from immune mice, significantly reduced the viability of phagocytized endospores and arthroconidia. The inability of macrophages from normal mice to kill C. immitis may in part be explained by the observation that C. immitis appeared to inhibit fusion of the phagosomes containing fungal spores with the lysosomes within the macrophages. However, fusion of phagosomes containing spores and lysosomes was observed in macrophages infected in the presence of lymphocytes from immune mice.

AB - Peritoneal macrophages from normal mice phagocytized arthroconidia and endospores of Coccidioides immitis without affecting the viability of the spores within 4 h after infection. In contrast, macrophages, when infected in the presence of lymphocytes from immune mice, significantly reduced the viability of phagocytized endospores and arthroconidia. The inability of macrophages from normal mice to kill C. immitis may in part be explained by the observation that C. immitis appeared to inhibit fusion of the phagosomes containing fungal spores with the lysosomes within the macrophages. However, fusion of phagosomes containing spores and lysosomes was observed in macrophages infected in the presence of lymphocytes from immune mice.

UR - http://www.scopus.com/inward/record.url?scp=0019772096&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019772096&partnerID=8YFLogxK

M3 - Article

C2 - 7309228

AN - SCOPUS:0019772096

VL - 34

SP - 347

EP - 353

JO - Infection and Immunity

JF - Infection and Immunity

SN - 0019-9567

IS - 2

ER -