Role of leukotriene B4 in the pathogenesis of Klebsiella pneumoniae-induced bovine mastitis.

D. M. Rose, S. N. Giri, S. J. Wood, James S Cullor

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Mastitis was induced in 4 lactating cows by inoculation of Klebsiella pneumoniae (10(7) organisms/ml) via the teat canal. Sterile isotonic saline solution (1 ml) was instilled into designated control quarters via the teat canal. Changes in milk leukotriene B4 and C4 (LTB4, LTC4) concentrations, milk somatic cell counts, and milk bovine serum albumin concentration were monitored over a 24-hour postinoculation period. Milk LTB4 concentration before inoculation in control quarters and quarters later to be infected was 376 +/- 45 and 326 +/- 56 pg/ml of milk, respectively. A significant (P less than 0.05) increase in milk LTB4 concentration in the infected quarters was first observed at postinoculation hour 6, and milk LTB4 concentration in infected quarters generally remained significantly high through postinoculation hour 14. Thereafter, milk LTB4 concentration in infected quarters was not significantly different from the concentration in control quarters. Measurable amounts of LTC4 were not detected in the milk of either control or infected quarters. Milk bovine serum albumin concentration in the infected quarters generally was high throughout the study, as were milk somatic cell counts. The results of this study suggested that LTB4 contributes to the pathogenesis of bovine mastitis.

Original languageEnglish (US)
Pages (from-to)915-918
Number of pages4
JournalAmerican Journal of Veterinary Research
Volume50
Issue number6
StatePublished - Jun 1989

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Bovine Mastitis
leukotrienes
Leukotriene B4
bovine mastitis
Klebsiella pneumoniae
Milk
pathogenesis
milk
Leukotriene C4
teats
bovine serum albumin
Bovine Serum Albumin
somatic cell count
Cell Count
Isotonic Solutions
Mastitis
Sodium Chloride
sodium chloride
mastitis

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Role of leukotriene B4 in the pathogenesis of Klebsiella pneumoniae-induced bovine mastitis. / Rose, D. M.; Giri, S. N.; Wood, S. J.; Cullor, James S.

In: American Journal of Veterinary Research, Vol. 50, No. 6, 06.1989, p. 915-918.

Research output: Contribution to journalArticle

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