Role of interleukin-6 and transforming growth factor-β in anorexia nervosa

Claire Pomeroy, Elke Eckert, Shuxian Hu, Beth Eiken, Margaret Mentink, Ross D. Crosby, Chun C. Chao

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Anorexia nervosa is a serious eating disorder characterized by extreme weight loss and abnormalities of the neuroendocrine and immune systems. To determine the potential role of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and transforming growth factor-β (TGF-β) in anorexia nervosa, serum concentrations of these cytokines were measured in patients with anorexia nervosa during starvation and after weight gain. Serum IL-6 and TGF-β concentrations were both significantly elevated during starvation and returned to levels comparable to those of normal-weight controls by the end of therapy. In contrast, serum TNF-α levels were undetectable in all patients and controls. Cytokines may play previously unsuspected roles in anorexia nervosa and its complications.

Original languageEnglish (US)
Pages (from-to)836-839
Number of pages4
JournalBiological Psychiatry
Volume36
Issue number12
DOIs
StatePublished - Dec 15 1994
Externally publishedYes

Fingerprint

Anorexia Nervosa
Transforming Growth Factors
Interleukin-6
Starvation
Tumor Necrosis Factor-alpha
Serum
Cytokines
Neurosecretory Systems
Weight Gain
Weight Loss
Immune System
Weights and Measures
Therapeutics

Keywords

  • anorexia nervosa
  • Cytokines
  • eating disorders
  • interleukin-6
  • transforming growth factor-β
  • tumor necrosis factor

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Pomeroy, C., Eckert, E., Hu, S., Eiken, B., Mentink, M., Crosby, R. D., & Chao, C. C. (1994). Role of interleukin-6 and transforming growth factor-β in anorexia nervosa. Biological Psychiatry, 36(12), 836-839. https://doi.org/10.1016/0006-3223(94)90594-0

Role of interleukin-6 and transforming growth factor-β in anorexia nervosa. / Pomeroy, Claire; Eckert, Elke; Hu, Shuxian; Eiken, Beth; Mentink, Margaret; Crosby, Ross D.; Chao, Chun C.

In: Biological Psychiatry, Vol. 36, No. 12, 15.12.1994, p. 836-839.

Research output: Contribution to journalArticle

Pomeroy, C, Eckert, E, Hu, S, Eiken, B, Mentink, M, Crosby, RD & Chao, CC 1994, 'Role of interleukin-6 and transforming growth factor-β in anorexia nervosa', Biological Psychiatry, vol. 36, no. 12, pp. 836-839. https://doi.org/10.1016/0006-3223(94)90594-0
Pomeroy C, Eckert E, Hu S, Eiken B, Mentink M, Crosby RD et al. Role of interleukin-6 and transforming growth factor-β in anorexia nervosa. Biological Psychiatry. 1994 Dec 15;36(12):836-839. https://doi.org/10.1016/0006-3223(94)90594-0
Pomeroy, Claire ; Eckert, Elke ; Hu, Shuxian ; Eiken, Beth ; Mentink, Margaret ; Crosby, Ross D. ; Chao, Chun C. / Role of interleukin-6 and transforming growth factor-β in anorexia nervosa. In: Biological Psychiatry. 1994 ; Vol. 36, No. 12. pp. 836-839.
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