Role of high-resolution magnetic resonance imaging for differentiating melanin-containing skin tumors

J. Maurer, Friedrich D Knollmann, D. Schlums, C. Garbe, T. J. Vogl, J. Bier, R. Felix

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

RATIONALE AND OBJECTIVES. The aim of the study was to evaluate the use of high resolution magnetic resonance imaging (MRI) for differentiation of melanin-containing skin tumors. METHODS. Twenty-seven melanocytic nevi and 18 malignant melanomas were examined by high resolution MRI. Signal intensities and signal-to-noise (SNR) and contrast-to-noise ratios (CNR) of the tumors were determined in unenhanced (T1, T2, water-suppression, and fat-suppression sequences) and contrast-enhanced images (T1 and fat-suppression sequences). The differences were tested for significance by a Wilcoxon test. RESULTS. Malignant melanomas differed from melanocytic nevi in that they displayed a higher SNR in T2-weighted and unenhanced and contrast-enhanced fat- suppression scans. Malignant melanomas exhibited a higher CNR than did benign lesions in unenhanced and contrast-enhanced fat-suppression sequences with dermis as reference tissue (P < 0.05) and in enhanced fat-suppression sequences with subcutis as reference tissue (P < 0.05). CONCLUSIONS. The usefulness of SNR and CNR analysis on MRI for the differentiation of malignant skin tumors from benign skin tumors of the melanin-containing system is limited. Clinical and histologic examinations are, further, the important step in evaluation of melanin-containing skin tumors.

Original languageEnglish (US)
Pages (from-to)638-643
Number of pages6
JournalInvestigative Radiology
Volume30
Issue number11
DOIs
StatePublished - 1995
Externally publishedYes

Keywords

  • benign melanocytic nevus
  • contrast media
  • Magnetic resonance imaging
  • melanoma
  • skin
  • surface coil

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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  • Cite this

    Maurer, J., Knollmann, F. D., Schlums, D., Garbe, C., Vogl, T. J., Bier, J., & Felix, R. (1995). Role of high-resolution magnetic resonance imaging for differentiating melanin-containing skin tumors. Investigative Radiology, 30(11), 638-643. https://doi.org/10.1097/00004424-199511000-00003