Role of high-order aberrations in senescent changes in spatial vision

Sarah L. Elliott, Stacey S. Choi, Nathan Doble, Joseph L. Hardy, Julia W. Evans, John S Werner

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

The contributions of optical and neural factors to age-related losses in spatial vision are not fully understood. We used closed-loop adaptive optics to test the visual benefit of correcting monochromatic high-order aberrations (HOAs) on spatial vision for observers ranging in age from 18 to 81 years. Contrast sensitivity was measured monocularly using a two-alternative forced-choice (2AFC) procedure for sinusoidal gratings over 6 mm and 3 mm pupil diameters. Visual acuity was measured using a spatial 4AFC procedure. Over a 6 mm pupil, young observers showed a large benefit of AO at high spatial frequencies, whereas older observers exhibited the greatest benefit at middle spatial frequencies, plus a significantly larger increase in visual acuity. When age-related miosis is controlled, young and old observers exhibited a similar benefit of AO for spatial vision. An increase in HOAs cannot account for the complete senescent decline in spatial vision. These results may indicate a larger role of additional optical factors when the impact of HOAs is removed, but also lend support for the importance of neural factors in age-related changes in spatial vision.

Original languageEnglish (US)
Article number24
JournalJournal of Vision
Volume9
Issue number2
DOIs
StatePublished - Feb 27 2009

Fingerprint

Age Factors
Pupil
Visual Acuity
Miosis
Contrast Sensitivity

Keywords

  • Adaptive optics
  • Aging
  • Contrast sensitivity
  • High-order aberration
  • Spatial vision

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

Cite this

Elliott, S. L., Choi, S. S., Doble, N., Hardy, J. L., Evans, J. W., & Werner, J. S. (2009). Role of high-order aberrations in senescent changes in spatial vision. Journal of Vision, 9(2), [24]. https://doi.org/10.1167/9.2.24

Role of high-order aberrations in senescent changes in spatial vision. / Elliott, Sarah L.; Choi, Stacey S.; Doble, Nathan; Hardy, Joseph L.; Evans, Julia W.; Werner, John S.

In: Journal of Vision, Vol. 9, No. 2, 24, 27.02.2009.

Research output: Contribution to journalArticle

Elliott, Sarah L. ; Choi, Stacey S. ; Doble, Nathan ; Hardy, Joseph L. ; Evans, Julia W. ; Werner, John S. / Role of high-order aberrations in senescent changes in spatial vision. In: Journal of Vision. 2009 ; Vol. 9, No. 2.
@article{21b64562f53e4fd7837a8bcd675e18fc,
title = "Role of high-order aberrations in senescent changes in spatial vision",
abstract = "The contributions of optical and neural factors to age-related losses in spatial vision are not fully understood. We used closed-loop adaptive optics to test the visual benefit of correcting monochromatic high-order aberrations (HOAs) on spatial vision for observers ranging in age from 18 to 81 years. Contrast sensitivity was measured monocularly using a two-alternative forced-choice (2AFC) procedure for sinusoidal gratings over 6 mm and 3 mm pupil diameters. Visual acuity was measured using a spatial 4AFC procedure. Over a 6 mm pupil, young observers showed a large benefit of AO at high spatial frequencies, whereas older observers exhibited the greatest benefit at middle spatial frequencies, plus a significantly larger increase in visual acuity. When age-related miosis is controlled, young and old observers exhibited a similar benefit of AO for spatial vision. An increase in HOAs cannot account for the complete senescent decline in spatial vision. These results may indicate a larger role of additional optical factors when the impact of HOAs is removed, but also lend support for the importance of neural factors in age-related changes in spatial vision.",
keywords = "Adaptive optics, Aging, Contrast sensitivity, High-order aberration, Spatial vision",
author = "Elliott, {Sarah L.} and Choi, {Stacey S.} and Nathan Doble and Hardy, {Joseph L.} and Evans, {Julia W.} and Werner, {John S}",
year = "2009",
month = "2",
day = "27",
doi = "10.1167/9.2.24",
language = "English (US)",
volume = "9",
journal = "Journal of Vision",
issn = "1534-7362",
publisher = "Association for Research in Vision and Ophthalmology Inc.",
number = "2",

}

TY - JOUR

T1 - Role of high-order aberrations in senescent changes in spatial vision

AU - Elliott, Sarah L.

AU - Choi, Stacey S.

AU - Doble, Nathan

AU - Hardy, Joseph L.

AU - Evans, Julia W.

AU - Werner, John S

PY - 2009/2/27

Y1 - 2009/2/27

N2 - The contributions of optical and neural factors to age-related losses in spatial vision are not fully understood. We used closed-loop adaptive optics to test the visual benefit of correcting monochromatic high-order aberrations (HOAs) on spatial vision for observers ranging in age from 18 to 81 years. Contrast sensitivity was measured monocularly using a two-alternative forced-choice (2AFC) procedure for sinusoidal gratings over 6 mm and 3 mm pupil diameters. Visual acuity was measured using a spatial 4AFC procedure. Over a 6 mm pupil, young observers showed a large benefit of AO at high spatial frequencies, whereas older observers exhibited the greatest benefit at middle spatial frequencies, plus a significantly larger increase in visual acuity. When age-related miosis is controlled, young and old observers exhibited a similar benefit of AO for spatial vision. An increase in HOAs cannot account for the complete senescent decline in spatial vision. These results may indicate a larger role of additional optical factors when the impact of HOAs is removed, but also lend support for the importance of neural factors in age-related changes in spatial vision.

AB - The contributions of optical and neural factors to age-related losses in spatial vision are not fully understood. We used closed-loop adaptive optics to test the visual benefit of correcting monochromatic high-order aberrations (HOAs) on spatial vision for observers ranging in age from 18 to 81 years. Contrast sensitivity was measured monocularly using a two-alternative forced-choice (2AFC) procedure for sinusoidal gratings over 6 mm and 3 mm pupil diameters. Visual acuity was measured using a spatial 4AFC procedure. Over a 6 mm pupil, young observers showed a large benefit of AO at high spatial frequencies, whereas older observers exhibited the greatest benefit at middle spatial frequencies, plus a significantly larger increase in visual acuity. When age-related miosis is controlled, young and old observers exhibited a similar benefit of AO for spatial vision. An increase in HOAs cannot account for the complete senescent decline in spatial vision. These results may indicate a larger role of additional optical factors when the impact of HOAs is removed, but also lend support for the importance of neural factors in age-related changes in spatial vision.

KW - Adaptive optics

KW - Aging

KW - Contrast sensitivity

KW - High-order aberration

KW - Spatial vision

UR - http://www.scopus.com/inward/record.url?scp=61649088143&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=61649088143&partnerID=8YFLogxK

U2 - 10.1167/9.2.24

DO - 10.1167/9.2.24

M3 - Article

C2 - 19271934

AN - SCOPUS:61649088143

VL - 9

JO - Journal of Vision

JF - Journal of Vision

SN - 1534-7362

IS - 2

M1 - 24

ER -