Abstract
Gamma interferon (IFN-γ) concentrations in blood, but not in lungs, rose significantly at 24 to 48 h after murine pulmonary infection with virulent pneumococci. In contrast, infection with avirulent pneumococcal strains produced minimal rises in serum IFN-γ concentrations. Compared with that of immunocompetent mice, mortality was appreciably increased after pulmonary infection of IFN-γ gene knockout mice, suggesting a protective role for IFN-γ in host response to pneumococcal disease.
Original language | English (US) |
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Pages (from-to) | 2975-2977 |
Number of pages | 3 |
Journal | Infection and Immunity |
Volume | 65 |
Issue number | 7 |
State | Published - 1997 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology