Role of gamma interferon in the pathogenesis of bacteremic pneumococcal pneumonia

J. B. Rubins; Claire Pomeroy

Role of gamma interferon in the pathogenesis of bacteremic pneumococcal pneumonia

J. B. Rubins, Claire Pomeroy

Research output: Contribution to journal › Article › peer-review

Abstract

Gamma interferon (IFN-γ) concentrations in blood, but not in lungs, rose significantly at 24 to 48 h after murine pulmonary infection with virulent pneumococci. In contrast, infection with avirulent pneumococcal strains produced minimal rises in serum IFN-γ concentrations. Compared with that of immunocompetent mice, mortality was appreciably increased after pulmonary infection of IFN-γ gene knockout mice, suggesting a protective role for IFN-γ in host response to pneumococcal disease.

Original language	English (US)
Pages (from-to)	2975-2977
Number of pages	3
Journal	Infection and Immunity
Volume	65
Issue number	7
State	Published - 1997
Externally published	Yes

ASJC Scopus subject areas

Immunology

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abstract = "Gamma interferon (IFN-γ) concentrations in blood, but not in lungs, rose significantly at 24 to 48 h after murine pulmonary infection with virulent pneumococci. In contrast, infection with avirulent pneumococcal strains produced minimal rises in serum IFN-γ concentrations. Compared with that of immunocompetent mice, mortality was appreciably increased after pulmonary infection of IFN-γ gene knockout mice, suggesting a protective role for IFN-γ in host response to pneumococcal disease.",

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