Role of gamma interferon in the pathogenesis of bacteremic pneumococcal pneumonia

J. B. Rubins, Claire Pomeroy

Research output: Contribution to journalArticlepeer-review

104 Scopus citations

Abstract

Gamma interferon (IFN-γ) concentrations in blood, but not in lungs, rose significantly at 24 to 48 h after murine pulmonary infection with virulent pneumococci. In contrast, infection with avirulent pneumococcal strains produced minimal rises in serum IFN-γ concentrations. Compared with that of immunocompetent mice, mortality was appreciably increased after pulmonary infection of IFN-γ gene knockout mice, suggesting a protective role for IFN-γ in host response to pneumococcal disease.

Original languageEnglish (US)
Pages (from-to)2975-2977
Number of pages3
JournalInfection and Immunity
Volume65
Issue number7
StatePublished - 1997
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

Fingerprint Dive into the research topics of 'Role of gamma interferon in the pathogenesis of bacteremic pneumococcal pneumonia'. Together they form a unique fingerprint.

Cite this