Abstract
Gamma interferon (IFN-γ) concentrations in blood, but not in lungs, rose significantly at 24 to 48 h after murine pulmonary infection with virulent pneumococci. In contrast, infection with avirulent pneumococcal strains produced minimal rises in serum IFN-γ concentrations. Compared with that of immunocompetent mice, mortality was appreciably increased after pulmonary infection of IFN-γ gene knockout mice, suggesting a protective role for IFN-γ in host response to pneumococcal disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2975-2977 |
| Number of pages | 3 |
| Journal | Infection and Immunity |
| Volume | 65 |
| Issue number | 7 |
| State | Published - 1997 |
| Externally published | Yes |
ASJC Scopus subject areas
- Immunology