Role of gamma interferon in the pathogenesis of bacteremic pneumococcal pneumonia

J. B. Rubins, Claire Pomeroy

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

Gamma interferon (IFN-γ) concentrations in blood, but not in lungs, rose significantly at 24 to 48 h after murine pulmonary infection with virulent pneumococci. In contrast, infection with avirulent pneumococcal strains produced minimal rises in serum IFN-γ concentrations. Compared with that of immunocompetent mice, mortality was appreciably increased after pulmonary infection of IFN-γ gene knockout mice, suggesting a protective role for IFN-γ in host response to pneumococcal disease.

Original languageEnglish (US)
Pages (from-to)2975-2977
Number of pages3
JournalInfection and Immunity
Volume65
Issue number7
StatePublished - 1997
Externally publishedYes

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Pneumococcal Pneumonia
Interferons
Interferon-gamma
Lung
Infection
Gene Knockout Techniques
Streptococcus pneumoniae
Knockout Mice
Mortality
Serum

ASJC Scopus subject areas

  • Immunology

Cite this

Role of gamma interferon in the pathogenesis of bacteremic pneumococcal pneumonia. / Rubins, J. B.; Pomeroy, Claire.

In: Infection and Immunity, Vol. 65, No. 7, 1997, p. 2975-2977.

Research output: Contribution to journalArticle

Rubins, J. B. ; Pomeroy, Claire. / Role of gamma interferon in the pathogenesis of bacteremic pneumococcal pneumonia. In: Infection and Immunity. 1997 ; Vol. 65, No. 7. pp. 2975-2977.
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