Abstract
Gamma interferon (IFN-γ) concentrations in blood, but not in lungs, rose significantly at 24 to 48 h after murine pulmonary infection with virulent pneumococci. In contrast, infection with avirulent pneumococcal strains produced minimal rises in serum IFN-γ concentrations. Compared with that of immunocompetent mice, mortality was appreciably increased after pulmonary infection of IFN-γ gene knockout mice, suggesting a protective role for IFN-γ in host response to pneumococcal disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2975-2977 |
| Number of pages | 3 |
| Journal | Infection and Immunity |
| Volume | 65 |
| Issue number | 7 |
| State | Published - 1997 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology
Cite this
Role of gamma interferon in the pathogenesis of bacteremic pneumococcal pneumonia. / Rubins, J. B.; Pomeroy, Claire.
In: Infection and Immunity, Vol. 65, No. 7, 1997, p. 2975-2977.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Role of gamma interferon in the pathogenesis of bacteremic pneumococcal pneumonia
AU - Rubins, J. B.
AU - Pomeroy, Claire
PY - 1997
Y1 - 1997
N2 - Gamma interferon (IFN-γ) concentrations in blood, but not in lungs, rose significantly at 24 to 48 h after murine pulmonary infection with virulent pneumococci. In contrast, infection with avirulent pneumococcal strains produced minimal rises in serum IFN-γ concentrations. Compared with that of immunocompetent mice, mortality was appreciably increased after pulmonary infection of IFN-γ gene knockout mice, suggesting a protective role for IFN-γ in host response to pneumococcal disease.
AB - Gamma interferon (IFN-γ) concentrations in blood, but not in lungs, rose significantly at 24 to 48 h after murine pulmonary infection with virulent pneumococci. In contrast, infection with avirulent pneumococcal strains produced minimal rises in serum IFN-γ concentrations. Compared with that of immunocompetent mice, mortality was appreciably increased after pulmonary infection of IFN-γ gene knockout mice, suggesting a protective role for IFN-γ in host response to pneumococcal disease.
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UR - http://www.scopus.com/inward/citedby.url?scp=0030978084&partnerID=8YFLogxK
M3 - Article
C2 - 9199475
AN - SCOPUS:0030978084
VL - 65
SP - 2975
EP - 2977
JO - Infection and Immunity
JF - Infection and Immunity
SN - 0019-9567
IS - 7
ER -