Role of extracellular matrix signaling cues in modulating cell fate commitment for cardiovascular tissue engineering

Karina H. Nakayama, Luqia Hou, Ngan F. Huang

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

It is generally agreed that engineered cardiovascular tissues require cellular interactions with the local milieu. Within the microenvironment, the extracellular matrix (ECM) is an important support structure that provides dynamic signaling cues in part through its chemical, physical, and mechanical properties. In response to ECM factors, cells activate biochemical and mechanotransduction pathways that modulate their survival, growth, migration, differentiation, and function. This Review describes the role of ECM chemical composition, spatial patterning, and mechanical stimulation in the specification of cardiovascular lineages, with a focus on stem cell differentiation, direct transdifferentiation, and endothelial-to-mesenchymal transition. The translational application of ECMs is discussed in the context of cardiovascular tissue engineering and regenerative medicine.

Original languageEnglish (US)
Pages (from-to)628-641
Number of pages14
JournalAdvanced healthcare materials
Volume3
Issue number5
DOIs
StatePublished - 2014
Externally publishedYes

Keywords

  • Cardiovascular
  • Cell fate
  • Extracellular matrix
  • Stem cells
  • Tissue engineering

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Pharmaceutical Science
  • Medicine(all)

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