Role of epoxide hydrolases in lipid metabolism

Christophe Morisseau

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

Epoxide hydrolases (EH), enzymes present in all living organisms, transform epoxide-containing lipids to 1,2-diols by the addition of a molecule of water. Many of these oxygenated lipid substrates have potent biological activities: host defense, control of development, regulation of blood pressure, inflammation, and pain. In general, the bioactivity of these natural epoxides is significantly reduced upon metabolism to diols. Thus, through the regulation of the titer of lipid epoxides, EHs have important and diverse biological roles with profound effects on the physiological state of the host organism. This review will discuss the biological activity of key lipid epoxides in mammals. In addition, the use of EH specific inhibitors will be highlighted as possible therapeutic disease interventions.

Original languageEnglish (US)
Pages (from-to)91-95
Number of pages5
JournalBiochimie
Volume95
Issue number1
DOIs
StatePublished - Jan 2013

Keywords

  • Cholesterol epoxide
  • Epoxide hydrolase
  • Epoxy-fatty acids
  • Juvenile hormone

ASJC Scopus subject areas

  • Biochemistry

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