Role of cephamycins in obstetrics and gynecology

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Infections of the female upper genital tract are usually polymicrobic, often involving mixed aerobic (facultative) and anaerobic bacteria. Optimal therapy provides coverage against aerobes (both gram positive and gram negative and especially the Enterobacteriaceae) and anaerobes (especially the beta-lactamase-producing gram-negative species, such as Bacteroides). A variety of antibiotics provide the broad spectrum of activity needed for these infections, including clindamycin plus an amino-glycoside, cephalosporins and cephamycins, imipenem, extended-spectrum penicillins and the beta-lactam agents combined with a beta-lactamase inhibitor. The cephamycins-cefoxitin, cefotetan and cefmetazole-have been shown to have a high rate of clinical efficacy and bacteriologic response. The cephalosporins are usually used for prophylaxis at the time of obstetric and gynecologic surgery. The cephamycins have recently undergone extensive evaluation for prophylaxis and have demonstrated comparable microbiologic and clinical efficacy. A pharmacokinetic comparison of cefoxitin, cefotetan and cefmetazole points to cefmetazole as a cost-effective alternative to cefoxitin and cefotetan for both prophylaxis and treatment of pelvic infections.

Original languageEnglish (US)
Pages (from-to)1064-1069
Number of pages6
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Volume35
Issue number11 SUPPL.
StatePublished - 1990

Fingerprint

Cephamycins
Cefmetazole
Cefotetan
Cefoxitin
Gynecology
Obstetrics
Cephalosporins
Obstetric Surgical Procedures
Pelvic Infection
Aerobic Bacteria
Gynecologic Surgical Procedures
Bacteroides
Anaerobic Bacteria
Clindamycin
Imipenem
beta-Lactams
Enterobacteriaceae
beta-Lactamases
Glycosides
Infection

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Role of cephamycins in obstetrics and gynecology. / Sweet, Richard L.

In: Journal of Reproductive Medicine for the Obstetrician and Gynecologist, Vol. 35, No. 11 SUPPL., 1990, p. 1064-1069.

Research output: Contribution to journalArticle

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