Abstract
The steroid induction agent, Althesin, infused intravenously in light anesthetic doses in otherwise unsedated man (84 μg kg-1 min-1) and rabbit (140 μg kg-1 min-1) causes similar autonomic and somatic effects. In the rabbit, the rise in heart rate (mainly due to central vagal blockade) and the selective depressant effects on respiratory rate are independent of CNS 5-hydroxytryptamine and noradrenaline. The rise in arterial pressure and the fall in hindlimb conductance is dependent on CNS 5-hydroxytryptamine and noradrenaline synthesizing neurons, which are probably arranged in series. These findings provide a working hypothesis for the mechanisms of action of Althesin on central cardiopulmonary controls in man.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 159-174 |
| Number of pages | 16 |
| Journal | Journal of the Autonomic Nervous System |
| Volume | 12 |
| Issue number | 2-3 |
| DOIs | |
| State | Published - 1985 |
| Externally published | Yes |
Fingerprint
Keywords
- Althesin
- blood pressure
- cardiopulmonary control
- heart rate
- noradrenergic neurons
- serotonergic neurons
- vasomotor control
ASJC Scopus subject areas
- Physiology
- Clinical Neurology
- Neuroscience(all)
Cite this
Role of central nervous system monoamines in cardiopulmonary effects of Althesin in rabbit and man. / Quail, A. W.; White, S. W.; Traugott, F. M.; Moore, Peter G.
In: Journal of the Autonomic Nervous System, Vol. 12, No. 2-3, 1985, p. 159-174.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Role of central nervous system monoamines in cardiopulmonary effects of Althesin in rabbit and man
AU - Quail, A. W.
AU - White, S. W.
AU - Traugott, F. M.
AU - Moore, Peter G
PY - 1985
Y1 - 1985
N2 - The steroid induction agent, Althesin, infused intravenously in light anesthetic doses in otherwise unsedated man (84 μg kg-1 min-1) and rabbit (140 μg kg-1 min-1) causes similar autonomic and somatic effects. In the rabbit, the rise in heart rate (mainly due to central vagal blockade) and the selective depressant effects on respiratory rate are independent of CNS 5-hydroxytryptamine and noradrenaline. The rise in arterial pressure and the fall in hindlimb conductance is dependent on CNS 5-hydroxytryptamine and noradrenaline synthesizing neurons, which are probably arranged in series. These findings provide a working hypothesis for the mechanisms of action of Althesin on central cardiopulmonary controls in man.
AB - The steroid induction agent, Althesin, infused intravenously in light anesthetic doses in otherwise unsedated man (84 μg kg-1 min-1) and rabbit (140 μg kg-1 min-1) causes similar autonomic and somatic effects. In the rabbit, the rise in heart rate (mainly due to central vagal blockade) and the selective depressant effects on respiratory rate are independent of CNS 5-hydroxytryptamine and noradrenaline. The rise in arterial pressure and the fall in hindlimb conductance is dependent on CNS 5-hydroxytryptamine and noradrenaline synthesizing neurons, which are probably arranged in series. These findings provide a working hypothesis for the mechanisms of action of Althesin on central cardiopulmonary controls in man.
KW - Althesin
KW - blood pressure
KW - cardiopulmonary control
KW - heart rate
KW - noradrenergic neurons
KW - serotonergic neurons
KW - vasomotor control
UR - http://www.scopus.com/inward/record.url?scp=0021925606&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021925606&partnerID=8YFLogxK
U2 - 10.1016/0165-1838(85)90058-X
DO - 10.1016/0165-1838(85)90058-X
M3 - Article
VL - 12
SP - 159
EP - 174
JO - Autonomic Neuroscience: Basic and Clinical
JF - Autonomic Neuroscience: Basic and Clinical
SN - 1566-0702
IS - 2-3
ER -