Role of central nervous system monoamines in cardiopulmonary effects of Althesin in rabbit and man

A. W. Quail; S. W. White; F. M. Traugott; Peter G Moore

doi:10.1016/0165-1838(85)90058-X

Role of central nervous system monoamines in cardiopulmonary effects of Althesin in rabbit and man

A. W. Quail, S. W. White, F. M. Traugott, Peter G Moore

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The steroid induction agent, Althesin, infused intravenously in light anesthetic doses in otherwise unsedated man (84 μg kg^-1 min^-1) and rabbit (140 μg kg^-1 min^-1) causes similar autonomic and somatic effects. In the rabbit, the rise in heart rate (mainly due to central vagal blockade) and the selective depressant effects on respiratory rate are independent of CNS 5-hydroxytryptamine and noradrenaline. The rise in arterial pressure and the fall in hindlimb conductance is dependent on CNS 5-hydroxytryptamine and noradrenaline synthesizing neurons, which are probably arranged in series. These findings provide a working hypothesis for the mechanisms of action of Althesin on central cardiopulmonary controls in man.

Original language	English (US)
Pages (from-to)	159-174
Number of pages	16
Journal	Journal of the Autonomic Nervous System
Volume	12
Issue number	2-3
DOIs	https://doi.org/10.1016/0165-1838(85)90058-X
State	Published - 1985
Externally published	Yes

Keywords

Althesin
blood pressure
cardiopulmonary control
heart rate
noradrenergic neurons
serotonergic neurons
vasomotor control

ASJC Scopus subject areas

Physiology
Clinical Neurology
Neuroscience(all)

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10.1016/0165-1838(85)90058-X

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title = "Role of central nervous system monoamines in cardiopulmonary effects of Althesin in rabbit and man",

abstract = "The steroid induction agent, Althesin, infused intravenously in light anesthetic doses in otherwise unsedated man (84 μg kg-1 min-1) and rabbit (140 μg kg-1 min-1) causes similar autonomic and somatic effects. In the rabbit, the rise in heart rate (mainly due to central vagal blockade) and the selective depressant effects on respiratory rate are independent of CNS 5-hydroxytryptamine and noradrenaline. The rise in arterial pressure and the fall in hindlimb conductance is dependent on CNS 5-hydroxytryptamine and noradrenaline synthesizing neurons, which are probably arranged in series. These findings provide a working hypothesis for the mechanisms of action of Althesin on central cardiopulmonary controls in man.",

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AU - Traugott, F. M.

AU - Moore, Peter G

PY - 1985

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