Role of CD8+ cells in controlling replication of nonpathogenic Simian Immunodeficiency Virus SIVmac1A11

Koen K.A. Van Rompay, Emily J. Blackwood, Gary Landucci, Don Forthal, Marta Marthas

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Infection of macaques with the avirulent molecular clone SIVmac1A11 results in transient low viremia and no disease. To investigate if this low viremia is solely due to intrinsic poor replication fitness or is mediated by efficient immune-mediated control, 5 macaques were inoculated intravenously with SIVmac1A11. Three animals that were depleted of CD8+ cells at the start of infection had more prolonged viremia with peak virus levels 1 to 2 logs higher than those of 2 animals that received a non-depleting control antibody. Thus, CD8+ cell-mediated immune responses play an important role in controlling SIVmac1A11 replication during acute viremia.

Original languageEnglish (US)
Article number22
JournalVirology Journal
Volume3
DOIs
StatePublished - Apr 3 2006

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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