Role of C-reactive protein in contributing to increased cardiovascular risk in metabolic syndrome

Sridevi Devaraj, Simona Valleggi, David Siegel, Ishwarlal Jialal

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Metabolic syndrome is associated with increased propensity for diabetes and cardiovascular disease. Lowgrade inflammation is characteristic of metabolic syndrome. C-reactive protein, the best characterized biomarker of inflammation, is also an independent predictor of future cardiovascular events. This review outlines the role of highsensitivityC-reactive protein in contributing to increased cardiovascular risk in metabolic syndrome by inducing endothelial cell dysfunction and activating monocytes.

Original languageEnglish (US)
Pages (from-to)110-118
Number of pages9
JournalCurrent Atherosclerosis Reports
Volume12
Issue number2
DOIs
StatePublished - Mar 2010
Externally publishedYes

Fingerprint

C-Reactive Protein
Inflammation
Monocytes
Cardiovascular Diseases
Endothelial Cells
Biomarkers
Proteins

Keywords

  • Cardiovascular risk
  • CRP
  • Inflammation
  • Metabolic syndrome

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

Cite this

Role of C-reactive protein in contributing to increased cardiovascular risk in metabolic syndrome. / Devaraj, Sridevi; Valleggi, Simona; Siegel, David; Jialal, Ishwarlal.

In: Current Atherosclerosis Reports, Vol. 12, No. 2, 03.2010, p. 110-118.

Research output: Contribution to journalArticle

Devaraj, Sridevi ; Valleggi, Simona ; Siegel, David ; Jialal, Ishwarlal. / Role of C-reactive protein in contributing to increased cardiovascular risk in metabolic syndrome. In: Current Atherosclerosis Reports. 2010 ; Vol. 12, No. 2. pp. 110-118.
@article{327f979e51b148f6a7fa239b9a5f71d8,
title = "Role of C-reactive protein in contributing to increased cardiovascular risk in metabolic syndrome",
abstract = "Metabolic syndrome is associated with increased propensity for diabetes and cardiovascular disease. Lowgrade inflammation is characteristic of metabolic syndrome. C-reactive protein, the best characterized biomarker of inflammation, is also an independent predictor of future cardiovascular events. This review outlines the role of highsensitivityC-reactive protein in contributing to increased cardiovascular risk in metabolic syndrome by inducing endothelial cell dysfunction and activating monocytes.",
keywords = "Cardiovascular risk, CRP, Inflammation, Metabolic syndrome",
author = "Sridevi Devaraj and Simona Valleggi and David Siegel and Ishwarlal Jialal",
year = "2010",
month = "3",
doi = "10.1007/s11883-010-0098-3",
language = "English (US)",
volume = "12",
pages = "110--118",
journal = "Current Atherosclerosis Reports",
issn = "1523-3804",
publisher = "Current Medicine Group",
number = "2",

}

TY - JOUR

T1 - Role of C-reactive protein in contributing to increased cardiovascular risk in metabolic syndrome

AU - Devaraj, Sridevi

AU - Valleggi, Simona

AU - Siegel, David

AU - Jialal, Ishwarlal

PY - 2010/3

Y1 - 2010/3

N2 - Metabolic syndrome is associated with increased propensity for diabetes and cardiovascular disease. Lowgrade inflammation is characteristic of metabolic syndrome. C-reactive protein, the best characterized biomarker of inflammation, is also an independent predictor of future cardiovascular events. This review outlines the role of highsensitivityC-reactive protein in contributing to increased cardiovascular risk in metabolic syndrome by inducing endothelial cell dysfunction and activating monocytes.

AB - Metabolic syndrome is associated with increased propensity for diabetes and cardiovascular disease. Lowgrade inflammation is characteristic of metabolic syndrome. C-reactive protein, the best characterized biomarker of inflammation, is also an independent predictor of future cardiovascular events. This review outlines the role of highsensitivityC-reactive protein in contributing to increased cardiovascular risk in metabolic syndrome by inducing endothelial cell dysfunction and activating monocytes.

KW - Cardiovascular risk

KW - CRP

KW - Inflammation

KW - Metabolic syndrome

UR - http://www.scopus.com/inward/record.url?scp=77953545358&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953545358&partnerID=8YFLogxK

U2 - 10.1007/s11883-010-0098-3

DO - 10.1007/s11883-010-0098-3

M3 - Article

C2 - 20425246

AN - SCOPUS:77953545358

VL - 12

SP - 110

EP - 118

JO - Current Atherosclerosis Reports

JF - Current Atherosclerosis Reports

SN - 1523-3804

IS - 2

ER -