Role of c-maf in chondrocyte differentiation: A review

Eunmee Hong, Paul E. di Cesare, Dominik R Haudenschild

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Chondrocyte differentiation in the growth plate is an important process for the longitudinal growth of endochondral bones. Sox9 and Runx2 are the most often-studied transcriptional regulators of the chondrocyte differentiation process, but the importance of additional factors is also becoming apparent. Mafs are a subfamily of the basic ZIP (bZIP) transcription factor superfamily, which act as key regulators of tissue-specific gene expression and terminal differentiation in many tissues. There is increasing evidence that c-Maf and its splicing variant Lc-Maf play a role in chondrocyte differentiation in a temporal-spatial manner. This review summarizes the functions of c-Maf in chondrocyte differentiation and discusses the possible role of c-Maf in osteoarthritis progression.

Original languageEnglish (US)
Pages (from-to)27-35
Number of pages9
JournalCartilage
Volume2
Issue number1
DOIs
StatePublished - Jan 2011

Keywords

  • Articular cartilage
  • Chondrocytes
  • Chondrogenesis
  • Mesenchymal stem cells
  • Signaling molecules

ASJC Scopus subject areas

  • Immunology and Allergy
  • Biomedical Engineering
  • Physical Therapy, Sports Therapy and Rehabilitation

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