### Abstract

A novel interpretation of pulmonary arterial input impedance was evaluated for the lung as a fractal vascular network. We hypothesized that local sources of reflection introduce trends of global reflection into the input impedance spectra. These trends are related to the network topology, geometry, and design according to R(b) = R(d)/(x), where R(b) is the branching ratio, R(d) is the diameter ratio, and x is the fractal dimension quantifying design. Simulations using values of R(d) and x, which were derived morphometrically, confirmed two patterns of global reflection: a continuous trend attributed to a single effective site of reflection caused by frequency-dependent sources of impedance contrast and a discrete trend arising from a longitudinal distribution of frequency-independent sources of reflection. The continuous trend depended only on the network parameter R(d), whereas the discrete trend depended on R(d) and x. Our results indicate that the impedance-matching properties of a deterministic pulmonary fractal network encode arterial geometry and topology via function and that typical values of R(d) and x for the pulmonary circulation facilitate shear stress amplification in its peripheral vessels. Thus, inasmuch as shear forces may be involved in the endothelial mechanisms for pathological, or physiological, vascular remodeling, broadband input impedance analysis may reveal interactions between network organization and vascular function.

Original language | English (US) |
---|---|

Pages (from-to) | 1033-1056 |

Number of pages | 24 |

Journal | Journal of Applied Physiology |

Volume | 80 |

Issue number | 3 |

State | Published - Mar 1996 |

### Fingerprint

### Keywords

- hemodynamics
- input impedance
- network connectivity

### ASJC Scopus subject areas

- Physiology
- Endocrinology
- Orthopedics and Sports Medicine
- Physical Therapy, Sports Therapy and Rehabilitation

### Cite this

*Journal of Applied Physiology*,

*80*(3), 1033-1056.

**Role of arterial design on pulse wave reflection in a fractal pulmonary network.** / Bennett, Stephen H.; Goetzman, Boyd W.; Milstein, Jay M; Pannu, Jatinder S.

Research output: Contribution to journal › Article

*Journal of Applied Physiology*, vol. 80, no. 3, pp. 1033-1056.

}

TY - JOUR

T1 - Role of arterial design on pulse wave reflection in a fractal pulmonary network

AU - Bennett, Stephen H.

AU - Goetzman, Boyd W.

AU - Milstein, Jay M

AU - Pannu, Jatinder S.

PY - 1996/3

Y1 - 1996/3

N2 - A novel interpretation of pulmonary arterial input impedance was evaluated for the lung as a fractal vascular network. We hypothesized that local sources of reflection introduce trends of global reflection into the input impedance spectra. These trends are related to the network topology, geometry, and design according to R(b) = R(d)/(x), where R(b) is the branching ratio, R(d) is the diameter ratio, and x is the fractal dimension quantifying design. Simulations using values of R(d) and x, which were derived morphometrically, confirmed two patterns of global reflection: a continuous trend attributed to a single effective site of reflection caused by frequency-dependent sources of impedance contrast and a discrete trend arising from a longitudinal distribution of frequency-independent sources of reflection. The continuous trend depended only on the network parameter R(d), whereas the discrete trend depended on R(d) and x. Our results indicate that the impedance-matching properties of a deterministic pulmonary fractal network encode arterial geometry and topology via function and that typical values of R(d) and x for the pulmonary circulation facilitate shear stress amplification in its peripheral vessels. Thus, inasmuch as shear forces may be involved in the endothelial mechanisms for pathological, or physiological, vascular remodeling, broadband input impedance analysis may reveal interactions between network organization and vascular function.

AB - A novel interpretation of pulmonary arterial input impedance was evaluated for the lung as a fractal vascular network. We hypothesized that local sources of reflection introduce trends of global reflection into the input impedance spectra. These trends are related to the network topology, geometry, and design according to R(b) = R(d)/(x), where R(b) is the branching ratio, R(d) is the diameter ratio, and x is the fractal dimension quantifying design. Simulations using values of R(d) and x, which were derived morphometrically, confirmed two patterns of global reflection: a continuous trend attributed to a single effective site of reflection caused by frequency-dependent sources of impedance contrast and a discrete trend arising from a longitudinal distribution of frequency-independent sources of reflection. The continuous trend depended only on the network parameter R(d), whereas the discrete trend depended on R(d) and x. Our results indicate that the impedance-matching properties of a deterministic pulmonary fractal network encode arterial geometry and topology via function and that typical values of R(d) and x for the pulmonary circulation facilitate shear stress amplification in its peripheral vessels. Thus, inasmuch as shear forces may be involved in the endothelial mechanisms for pathological, or physiological, vascular remodeling, broadband input impedance analysis may reveal interactions between network organization and vascular function.

KW - hemodynamics

KW - input impedance

KW - network connectivity

UR - http://www.scopus.com/inward/record.url?scp=0029912920&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029912920&partnerID=8YFLogxK

M3 - Article

VL - 80

SP - 1033

EP - 1056

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 3

ER -