Role of arterial design on pulse wave reflection in a fractal pulmonary network

Stephen H. Bennett, Boyd W. Goetzman, Jay M Milstein, Jatinder S. Pannu

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

A novel interpretation of pulmonary arterial input impedance was evaluated for the lung as a fractal vascular network. We hypothesized that local sources of reflection introduce trends of global reflection into the input impedance spectra. These trends are related to the network topology, geometry, and design according to R(b) = R(d)/(x), where R(b) is the branching ratio, R(d) is the diameter ratio, and x is the fractal dimension quantifying design. Simulations using values of R(d) and x, which were derived morphometrically, confirmed two patterns of global reflection: a continuous trend attributed to a single effective site of reflection caused by frequency-dependent sources of impedance contrast and a discrete trend arising from a longitudinal distribution of frequency-independent sources of reflection. The continuous trend depended only on the network parameter R(d), whereas the discrete trend depended on R(d) and x. Our results indicate that the impedance-matching properties of a deterministic pulmonary fractal network encode arterial geometry and topology via function and that typical values of R(d) and x for the pulmonary circulation facilitate shear stress amplification in its peripheral vessels. Thus, inasmuch as shear forces may be involved in the endothelial mechanisms for pathological, or physiological, vascular remodeling, broadband input impedance analysis may reveal interactions between network organization and vascular function.

Original languageEnglish (US)
Pages (from-to)1033-1056
Number of pages24
JournalJournal of Applied Physiology
Volume80
Issue number3
StatePublished - Mar 1996

Keywords

  • hemodynamics
  • input impedance
  • network connectivity

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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    Bennett, S. H., Goetzman, B. W., Milstein, J. M., & Pannu, J. S. (1996). Role of arterial design on pulse wave reflection in a fractal pulmonary network. Journal of Applied Physiology, 80(3), 1033-1056.