Role of antiribosomal P protein antibodies in the diagnosis of lupus isolated to the central nervous system

Mark A. Agius, Jane W. Chan, Stephen Chung, Eun Kyu Lee

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Background: When lupus presents with isolated central nervous system findings, the usual serologic markers are often absent and diagnostic difficulty with a delay in treatment is common. Objective: To report the usefulness of antiribosomal P protein antibodies in the diagnosis of lupus isolated to the central nervous system when results of tests for anti- double-stranded DNA antibodies are negative. Design: Case report. Setting: University medical center. Patient: The patient was evaluated and treated on referral and followed up for 1 year. Results: We describe a patient with acute onset of psychosis followed by coma and focal clonic movements with undetectable DNA antibodies. Serum antiribosomal P protein antibody levels were elevated. Steroid therapy was followed by marked clinical improvement and a decrease in antibody titer. Conclusion: Antiribosomal P protein antibodies provide an important confirmatory test for the diagnosis of lupus isolated to the central nervous system when results of tests for anti- double-stranded DNA antibodies are negative.

Original languageEnglish (US)
Pages (from-to)862-864
Number of pages3
JournalArchives of Neurology
Volume54
Issue number7
StatePublished - 1997

    Fingerprint

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this