Rod plateaux during dark adaptation in Sorsby's fundus dystrophy and vitamin A deficiency

Artur V. Cideciyan, Edward N Pugh Jr, Trevor D. Lamb, Yijun Huang, Samuel G. Jacobson

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Purpose. To investigate the transitory plateaux observed during dark adaptation after partial bleaches in Sorsby's fundus dystrophy (SFD) and in systemic vitamin A deficiency (VAD). Methods. Psychophysical dark adaptation functions were measured after bleaching exposures isomerizing from 2% to 99% of the rhodopsin. Narrow-band stimuli of 1.7°diameter and 200 msec duration were presented at an eccentricity of 30°. Results. After a full bleach, the patients showed typical dark adaptation abnormalities reported for these diseases. The cone recovery was slowed, and the time to the rod-cone break was delayed; the final phase of rod recovery was also slowed but led to a normal final rod threshold. After partial bleaches, short wavelength stimuli produced a biphasic recovery function, with an initial rapid component and plateau, followed by a subsequent break-off and eventual return to prebleach thresholds. Action spectra obtained during the plateaux were consistent with thresholds for shorter wavelength stimuli mediated by rods and thresholds for longer wavelength stimuli mediated by cones. In the patient with VAD, vitamin A supplementation led to accelerated recovery and disappearance of the transitory rod plateaux. Conclusions. The biphasic dark adaptation functions resulting from fractional bleaches in SFD and VAD appear superficially similar to the classic biphasic adaptation functions obtained with full bleaches. However, thresholds during the plateaux are lower than the cone threshold, and action spectra indicate rod mediation. These transitory rod plateaux may increase our understanding of the normal visual cycle and its perturbation in retinal disease.

Original languageEnglish (US)
Pages (from-to)1786-1794
Number of pages9
JournalInvestigative Ophthalmology and Visual Science
Volume38
Issue number9
StatePublished - Aug 1997
Externally publishedYes

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Dark Adaptation
Vitamin A Deficiency
Retinal Diseases
Vertebrate Photoreceptor Cells
Rhodopsin
Recovery of Function
Vitamin A
Action Spectrum

Keywords

  • Dark adaptation
  • Hereditary retinal degenerations
  • TIMP3 gene mutation
  • Visual cycle
  • Vitamin A

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Rod plateaux during dark adaptation in Sorsby's fundus dystrophy and vitamin A deficiency. / Cideciyan, Artur V.; Pugh Jr, Edward N; Lamb, Trevor D.; Huang, Yijun; Jacobson, Samuel G.

In: Investigative Ophthalmology and Visual Science, Vol. 38, No. 9, 08.1997, p. 1786-1794.

Research output: Contribution to journalArticle

Cideciyan, Artur V. ; Pugh Jr, Edward N ; Lamb, Trevor D. ; Huang, Yijun ; Jacobson, Samuel G. / Rod plateaux during dark adaptation in Sorsby's fundus dystrophy and vitamin A deficiency. In: Investigative Ophthalmology and Visual Science. 1997 ; Vol. 38, No. 9. pp. 1786-1794.
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abstract = "Purpose. To investigate the transitory plateaux observed during dark adaptation after partial bleaches in Sorsby's fundus dystrophy (SFD) and in systemic vitamin A deficiency (VAD). Methods. Psychophysical dark adaptation functions were measured after bleaching exposures isomerizing from 2{\%} to 99{\%} of the rhodopsin. Narrow-band stimuli of 1.7°diameter and 200 msec duration were presented at an eccentricity of 30°. Results. After a full bleach, the patients showed typical dark adaptation abnormalities reported for these diseases. The cone recovery was slowed, and the time to the rod-cone break was delayed; the final phase of rod recovery was also slowed but led to a normal final rod threshold. After partial bleaches, short wavelength stimuli produced a biphasic recovery function, with an initial rapid component and plateau, followed by a subsequent break-off and eventual return to prebleach thresholds. Action spectra obtained during the plateaux were consistent with thresholds for shorter wavelength stimuli mediated by rods and thresholds for longer wavelength stimuli mediated by cones. In the patient with VAD, vitamin A supplementation led to accelerated recovery and disappearance of the transitory rod plateaux. Conclusions. The biphasic dark adaptation functions resulting from fractional bleaches in SFD and VAD appear superficially similar to the classic biphasic adaptation functions obtained with full bleaches. However, thresholds during the plateaux are lower than the cone threshold, and action spectra indicate rod mediation. These transitory rod plateaux may increase our understanding of the normal visual cycle and its perturbation in retinal disease.",
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N2 - Purpose. To investigate the transitory plateaux observed during dark adaptation after partial bleaches in Sorsby's fundus dystrophy (SFD) and in systemic vitamin A deficiency (VAD). Methods. Psychophysical dark adaptation functions were measured after bleaching exposures isomerizing from 2% to 99% of the rhodopsin. Narrow-band stimuli of 1.7°diameter and 200 msec duration were presented at an eccentricity of 30°. Results. After a full bleach, the patients showed typical dark adaptation abnormalities reported for these diseases. The cone recovery was slowed, and the time to the rod-cone break was delayed; the final phase of rod recovery was also slowed but led to a normal final rod threshold. After partial bleaches, short wavelength stimuli produced a biphasic recovery function, with an initial rapid component and plateau, followed by a subsequent break-off and eventual return to prebleach thresholds. Action spectra obtained during the plateaux were consistent with thresholds for shorter wavelength stimuli mediated by rods and thresholds for longer wavelength stimuli mediated by cones. In the patient with VAD, vitamin A supplementation led to accelerated recovery and disappearance of the transitory rod plateaux. Conclusions. The biphasic dark adaptation functions resulting from fractional bleaches in SFD and VAD appear superficially similar to the classic biphasic adaptation functions obtained with full bleaches. However, thresholds during the plateaux are lower than the cone threshold, and action spectra indicate rod mediation. These transitory rod plateaux may increase our understanding of the normal visual cycle and its perturbation in retinal disease.

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