Abstract
A microcomputer-driven reaction protocol has been developed that allows a researcher to initiate a series of experiments which are performed automatically by a robot. The current system is capable of carrying out as many as nine simultaneous, operator-specified reactions complete with automated workup (aliquot quenching, extraction, and plug filtration) combined with automated HPLC yield analysis. Automated reactor cleaning allows multiple runs to be made without operator intervention. Application of this system to the yield optimization of a highly functionalized vinyl sulfone is described.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 7143-7145 |
| Number of pages | 3 |
| Journal | Journal of the American Chemical Society |
| Volume | 106 |
| Issue number | 23 |
| State | Published - Jan 1 1984 |
| Externally published | Yes |
ASJC Scopus subject areas
- Chemistry(all)
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Frisbee, A. R., Nantz, M. H., Kramer, G. W., & Fuchs, P. L. (1984). ROBOTIC ORCHESTRATION OF ORGANIC REACTIONS: YIELD OPTIMIZATION VIA AN AUTOMATED SYSTEM WITH OPERATOR-SPECIFIED REACTION SEQUENCES. Journal of the American Chemical Society, 106(23), 7143-7145.