ROBOTIC ORCHESTRATION OF ORGANIC REACTIONS: YIELD OPTIMIZATION VIA AN AUTOMATED SYSTEM WITH OPERATOR-SPECIFIED REACTION SEQUENCES.

A. R. Frisbee, M. H. Nantz, G. W. Kramer, P. L. Fuchs

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

A microcomputer-driven reaction protocol has been developed that allows a researcher to initiate a series of experiments which are performed automatically by a robot. The current system is capable of carrying out as many as nine simultaneous, operator-specified reactions complete with automated workup (aliquot quenching, extraction, and plug filtration) combined with automated HPLC yield analysis. Automated reactor cleaning allows multiple runs to be made without operator intervention. Application of this system to the yield optimization of a highly functionalized vinyl sulfone is described.

Original languageEnglish (US)
Pages (from-to)7143-7145
Number of pages3
JournalJournal of the American Chemical Society
Volume106
Issue number23
StatePublished - Jan 1 1984
Externally publishedYes

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ASJC Scopus subject areas

  • Chemistry(all)

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