ROBOTIC ORCHESTRATION OF ORGANIC REACTIONS: YIELD OPTIMIZATION VIA AN AUTOMATED SYSTEM WITH OPERATOR-SPECIFIED REACTION SEQUENCES.

A. R. Frisbee; M. H. Nantz; G. W. Kramer; P. L. Fuchs

ROBOTIC ORCHESTRATION OF ORGANIC REACTIONS: YIELD OPTIMIZATION VIA AN AUTOMATED SYSTEM WITH OPERATOR-SPECIFIED REACTION SEQUENCES.

A. R. Frisbee, M. H. Nantz, G. W. Kramer, P. L. Fuchs

Research output: Contribution to journal › Article › peer-review

Abstract

A microcomputer-driven reaction protocol has been developed that allows a researcher to initiate a series of experiments which are performed automatically by a robot. The current system is capable of carrying out as many as nine simultaneous, operator-specified reactions complete with automated workup (aliquot quenching, extraction, and plug filtration) combined with automated HPLC yield analysis. Automated reactor cleaning allows multiple runs to be made without operator intervention. Application of this system to the yield optimization of a highly functionalized vinyl sulfone is described.

Original language	English (US)
Pages (from-to)	7143-7145
Number of pages	3
Journal	Journal of the American Chemical Society
Volume	106
Issue number	23
State	Published - Jan 1 1984
Externally published	Yes

ASJC Scopus subject areas

Chemistry(all)

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title = "ROBOTIC ORCHESTRATION OF ORGANIC REACTIONS: YIELD OPTIMIZATION VIA AN AUTOMATED SYSTEM WITH OPERATOR-SPECIFIED REACTION SEQUENCES.",

abstract = "A microcomputer-driven reaction protocol has been developed that allows a researcher to initiate a series of experiments which are performed automatically by a robot. The current system is capable of carrying out as many as nine simultaneous, operator-specified reactions complete with automated workup (aliquot quenching, extraction, and plug filtration) combined with automated HPLC yield analysis. Automated reactor cleaning allows multiple runs to be made without operator intervention. Application of this system to the yield optimization of a highly functionalized vinyl sulfone is described.",

author = "Frisbee, {A. R.} and Nantz, {M. H.} and Kramer, {G. W.} and Fuchs, {P. L.}",

year = "1984",

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language = "English (US)",

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T2 - YIELD OPTIMIZATION VIA AN AUTOMATED SYSTEM WITH OPERATOR-SPECIFIED REACTION SEQUENCES.

AU - Frisbee, A. R.

AU - Nantz, M. H.

AU - Kramer, G. W.

AU - Fuchs, P. L.

PY - 1984/1/1

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