RNPC1, an RNA-binding protein and a p53 target, regulates macrophage inhibitory cytokine-1 (MIC-1) expression through mRNA stability

Tiffany Yin, Seong Jun Cho, Xinbin Chen

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Background: The mechanism by which MIC-1 expression is regulated post-transcriptionally is not clear. Results: MIC-1 transcript can be stabilized and mediate cell growth suppression via RNPC1. Conclusion: RNPC1 can increase MIC-1 expression and inhibit cell growth by binding its 3-UTR. Significance: A novel post-transcriptional mechanism is found to regulate MIC-1 expression by RNPC1.

Original languageEnglish (US)
Pages (from-to)23680-23686
Number of pages7
JournalJournal of Biological Chemistry
Volume288
Issue number33
DOIs
StatePublished - Aug 16 2013

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

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