RNA splicing: Advantages of parallel processing

Gunnar von Heijne, Michael A. Savageau

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Parallel and sequential modes of RNA processing are systematically compared by an analysis of the relevant kinetic reaction schemes. The parallel mode is shown to be superior in the sense that it allows molecules to be processed with larger numbers of introns, smaller losses of immature intermediates, and shorter processing times. It also is more sensitive to variations in the rate constants for individual splice-reactions, and hence more amenable to evolutionary refinements. Quantitatively, the parallel mode agrees well with published experimental data.

Original languageEnglish (US)
Pages (from-to)563-574
Number of pages12
JournalJournal of Theoretical Biology
Volume98
Issue number4
DOIs
StatePublished - Oct 21 1982
Externally publishedYes

Fingerprint

RNA splicing
RNA Splicing
reaction kinetics
Parallel Processing
RNA
Introns
introns
immatures
Processing
Reaction kinetics
Rate constants
Reaction Kinetics
Rate Constant
Molecules
Refinement
Experimental Data

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

RNA splicing : Advantages of parallel processing. / von Heijne, Gunnar; Savageau, Michael A.

In: Journal of Theoretical Biology, Vol. 98, No. 4, 21.10.1982, p. 563-574.

Research output: Contribution to journalArticle

von Heijne, Gunnar ; Savageau, Michael A. / RNA splicing : Advantages of parallel processing. In: Journal of Theoretical Biology. 1982 ; Vol. 98, No. 4. pp. 563-574.
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