Abstract
Parallel and sequential modes of RNA processing are systematically compared by an analysis of the relevant kinetic reaction schemes. The parallel mode is shown to be superior in the sense that it allows molecules to be processed with larger numbers of introns, smaller losses of immature intermediates, and shorter processing times. It also is more sensitive to variations in the rate constants for individual splice-reactions, and hence more amenable to evolutionary refinements. Quantitatively, the parallel mode agrees well with published experimental data.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 563-574 |
| Number of pages | 12 |
| Journal | Journal of Theoretical Biology |
| Volume | 98 |
| Issue number | 4 |
| DOIs | |
| State | Published - Oct 21 1982 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
Cite this
RNA splicing : Advantages of parallel processing. / von Heijne, Gunnar; Savageau, Michael A.
In: Journal of Theoretical Biology, Vol. 98, No. 4, 21.10.1982, p. 563-574.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - RNA splicing
T2 - Advantages of parallel processing
AU - von Heijne, Gunnar
AU - Savageau, Michael A.
PY - 1982/10/21
Y1 - 1982/10/21
N2 - Parallel and sequential modes of RNA processing are systematically compared by an analysis of the relevant kinetic reaction schemes. The parallel mode is shown to be superior in the sense that it allows molecules to be processed with larger numbers of introns, smaller losses of immature intermediates, and shorter processing times. It also is more sensitive to variations in the rate constants for individual splice-reactions, and hence more amenable to evolutionary refinements. Quantitatively, the parallel mode agrees well with published experimental data.
AB - Parallel and sequential modes of RNA processing are systematically compared by an analysis of the relevant kinetic reaction schemes. The parallel mode is shown to be superior in the sense that it allows molecules to be processed with larger numbers of introns, smaller losses of immature intermediates, and shorter processing times. It also is more sensitive to variations in the rate constants for individual splice-reactions, and hence more amenable to evolutionary refinements. Quantitatively, the parallel mode agrees well with published experimental data.
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UR - http://www.scopus.com/inward/citedby.url?scp=0020446211&partnerID=8YFLogxK
U2 - 10.1016/0022-5193(82)90138-2
DO - 10.1016/0022-5193(82)90138-2
M3 - Article
C2 - 7154689
AN - SCOPUS:0020446211
VL - 98
SP - 563
EP - 574
JO - Journal of Theoretical Biology
JF - Journal of Theoretical Biology
SN - 0022-5193
IS - 4
ER -