RNA splicing: Advantages of parallel processing

Gunnar von Heijne; Michael A. Savageau

doi:10.1016/0022-5193(82)90138-2

RNA splicing: Advantages of parallel processing

Gunnar von Heijne, Michael A. Savageau

Research output: Contribution to journal › Article

1 Scopus citations

Abstract

Parallel and sequential modes of RNA processing are systematically compared by an analysis of the relevant kinetic reaction schemes. The parallel mode is shown to be superior in the sense that it allows molecules to be processed with larger numbers of introns, smaller losses of immature intermediates, and shorter processing times. It also is more sensitive to variations in the rate constants for individual splice-reactions, and hence more amenable to evolutionary refinements. Quantitatively, the parallel mode agrees well with published experimental data.

Original language	English (US)
Pages (from-to)	563-574
Number of pages	12
Journal	Journal of Theoretical Biology
Volume	98
Issue number	4
DOIs	https://doi.org/10.1016/0022-5193(82)90138-2
State	Published - Oct 21 1982
Externally published	Yes

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ASJC Scopus subject areas

Agricultural and Biological Sciences(all)

Cite this

von Heijne, G., & Savageau, M. A. (1982). RNA splicing: Advantages of parallel processing. Journal of Theoretical Biology, 98(4), 563-574. https://doi.org/10.1016/0022-5193(82)90138-2

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10.1016/0022-5193(82)90138-2