RNA as a stroke biomarker

Nicholas E. Swyngedouw, Glen C. Jickling

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A biomarker to aid in the diagnosis of ischemic stroke and its causes would be of value in acute clinical practice. It could have applications to aid in acute stroke treatment decisions for tissue plasminogen activator and/or the triage to endovascular therapy. A stroke biomarker may also be useful to identify stroke etiology and guide stroke prevention treatments. This review provides an overview of RNA as a novel biomarker for the diagnosis and assessment of ischemic stroke. Topics addressed include RNA to identify acute ischemic stroke; RNA to identify transient ischemic attack; RNA to predict large vessel, cardioembolic and small vessel cause of stroke; and RNA to predict risk of tissue plasminogen activator related hemorrhagic transformation. Emerging methods to measure RNA as a point-of-care assay include microfluidics sorting and electrochemical sensors.

Original languageEnglish (US)
Pages (from-to)71-78
Number of pages8
JournalFuture Neurology
Volume12
Issue number2
DOIs
StatePublished - May 1 2017

Fingerprint

Biomarkers
Stroke
RNA
Tissue Plasminogen Activator
Point-of-Care Systems
Microfluidics
Triage
Transient Ischemic Attack

Keywords

  • biomarker
  • blood
  • gene expression
  • genomics
  • ischemic stroke
  • RNA

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Swyngedouw, N. E., & Jickling, G. C. (2017). RNA as a stroke biomarker. Future Neurology, 12(2), 71-78. https://doi.org/10.2217/fnl-2016-0034

RNA as a stroke biomarker. / Swyngedouw, Nicholas E.; Jickling, Glen C.

In: Future Neurology, Vol. 12, No. 2, 01.05.2017, p. 71-78.

Research output: Contribution to journalArticle

Swyngedouw, NE & Jickling, GC 2017, 'RNA as a stroke biomarker', Future Neurology, vol. 12, no. 2, pp. 71-78. https://doi.org/10.2217/fnl-2016-0034
Swyngedouw NE, Jickling GC. RNA as a stroke biomarker. Future Neurology. 2017 May 1;12(2):71-78. https://doi.org/10.2217/fnl-2016-0034
Swyngedouw, Nicholas E. ; Jickling, Glen C. / RNA as a stroke biomarker. In: Future Neurology. 2017 ; Vol. 12, No. 2. pp. 71-78.
@article{aa8128865b4b477891a36cff55b06adf,
title = "RNA as a stroke biomarker",
abstract = "A biomarker to aid in the diagnosis of ischemic stroke and its causes would be of value in acute clinical practice. It could have applications to aid in acute stroke treatment decisions for tissue plasminogen activator and/or the triage to endovascular therapy. A stroke biomarker may also be useful to identify stroke etiology and guide stroke prevention treatments. This review provides an overview of RNA as a novel biomarker for the diagnosis and assessment of ischemic stroke. Topics addressed include RNA to identify acute ischemic stroke; RNA to identify transient ischemic attack; RNA to predict large vessel, cardioembolic and small vessel cause of stroke; and RNA to predict risk of tissue plasminogen activator related hemorrhagic transformation. Emerging methods to measure RNA as a point-of-care assay include microfluidics sorting and electrochemical sensors.",
keywords = "biomarker, blood, gene expression, genomics, ischemic stroke, RNA",
author = "Swyngedouw, {Nicholas E.} and Jickling, {Glen C.}",
year = "2017",
month = "5",
day = "1",
doi = "10.2217/fnl-2016-0034",
language = "English (US)",
volume = "12",
pages = "71--78",
journal = "Future Neurology",
issn = "1479-6708",
publisher = "Future Medicine Ltd.",
number = "2",

}

TY - JOUR

T1 - RNA as a stroke biomarker

AU - Swyngedouw, Nicholas E.

AU - Jickling, Glen C.

PY - 2017/5/1

Y1 - 2017/5/1

N2 - A biomarker to aid in the diagnosis of ischemic stroke and its causes would be of value in acute clinical practice. It could have applications to aid in acute stroke treatment decisions for tissue plasminogen activator and/or the triage to endovascular therapy. A stroke biomarker may also be useful to identify stroke etiology and guide stroke prevention treatments. This review provides an overview of RNA as a novel biomarker for the diagnosis and assessment of ischemic stroke. Topics addressed include RNA to identify acute ischemic stroke; RNA to identify transient ischemic attack; RNA to predict large vessel, cardioembolic and small vessel cause of stroke; and RNA to predict risk of tissue plasminogen activator related hemorrhagic transformation. Emerging methods to measure RNA as a point-of-care assay include microfluidics sorting and electrochemical sensors.

AB - A biomarker to aid in the diagnosis of ischemic stroke and its causes would be of value in acute clinical practice. It could have applications to aid in acute stroke treatment decisions for tissue plasminogen activator and/or the triage to endovascular therapy. A stroke biomarker may also be useful to identify stroke etiology and guide stroke prevention treatments. This review provides an overview of RNA as a novel biomarker for the diagnosis and assessment of ischemic stroke. Topics addressed include RNA to identify acute ischemic stroke; RNA to identify transient ischemic attack; RNA to predict large vessel, cardioembolic and small vessel cause of stroke; and RNA to predict risk of tissue plasminogen activator related hemorrhagic transformation. Emerging methods to measure RNA as a point-of-care assay include microfluidics sorting and electrochemical sensors.

KW - biomarker

KW - blood

KW - gene expression

KW - genomics

KW - ischemic stroke

KW - RNA

UR - http://www.scopus.com/inward/record.url?scp=85019040129&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85019040129&partnerID=8YFLogxK

U2 - 10.2217/fnl-2016-0034

DO - 10.2217/fnl-2016-0034

M3 - Article

AN - SCOPUS:85019040129

VL - 12

SP - 71

EP - 78

JO - Future Neurology

JF - Future Neurology

SN - 1479-6708

IS - 2

ER -