Risk predictors of stroke and mortality after ablation for atrial fibrillation

the California experience 2005-2009

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

BACKGROUND: Ablation (ABL) is a second-line therapy for the management of atrial fibrillation (AF). Single-center studies have demonstrated the safety and efficacy of ABL; however, the low event rates render it difficult to assess predictors of major adverse events.

OBJECTIVE: The purpose of this study was to determine the population-based incidence of data and risk factors for both stroke <30 days and death after AF ABL.

METHODS: Patients (n = 6207) identified as having undergone AF ABL between 2005 and 2009 by the California Ambulatory Surgery Database in 97 nonfederal hospitals in California were linked to the California Patient Discharge Database and to a master death registry. Data from these patients were analyzed for primary outcomes of 30-day death and ischemic stroke. Independent risk factors for these end-points were determined.

RESULTS: Mean patient age was 61.9 years, and the majority of the patients were men. Thirty-day mortality and stroke after ABL were 0.39% and 0.61%, respectively. Independent predictors of death were age ≥80 years (odds ratio [OR] 8.2, 95% confidence interval [CI] 1.5-43) and heart failure (OR 9.2, 95% CI 3.0-28). Prior stroke/transient ischemic attack/stroke was the only independent predictor for stroke (OR 6.3, 95% CI 3-13).

CONCLUSION: In our large population-based study, we found higher procedure-related mortality but comparable stroke rate after AF ABL than previously reported. Age ≥80 years and heart failure was each independently associated with >8-fold increase in odds of death. The only significant predictor of stroke was prior stroke/transient ischemic attack. These findings may aid in patient selection for AF ABL.

Original languageEnglish (US)
Pages (from-to)1898-1903
Number of pages6
JournalHeart Rhythm
Volume11
Issue number11
DOIs
StatePublished - Nov 1 2014

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Atrial Fibrillation
Stroke
Mortality
Transient Ischemic Attack
Patient Selection
Safety
Incidence
Population
Therapeutics

Keywords

  • Ablation
  • Atrial fibrillation
  • Mortality
  • Stroke

ASJC Scopus subject areas

  • Medicine(all)

Cite this

@article{18ad3eaab2664ad899f9a5fda72631c1,
title = "Risk predictors of stroke and mortality after ablation for atrial fibrillation: the California experience 2005-2009",
abstract = "BACKGROUND: Ablation (ABL) is a second-line therapy for the management of atrial fibrillation (AF). Single-center studies have demonstrated the safety and efficacy of ABL; however, the low event rates render it difficult to assess predictors of major adverse events.OBJECTIVE: The purpose of this study was to determine the population-based incidence of data and risk factors for both stroke <30 days and death after AF ABL.METHODS: Patients (n = 6207) identified as having undergone AF ABL between 2005 and 2009 by the California Ambulatory Surgery Database in 97 nonfederal hospitals in California were linked to the California Patient Discharge Database and to a master death registry. Data from these patients were analyzed for primary outcomes of 30-day death and ischemic stroke. Independent risk factors for these end-points were determined.RESULTS: Mean patient age was 61.9 years, and the majority of the patients were men. Thirty-day mortality and stroke after ABL were 0.39{\%} and 0.61{\%}, respectively. Independent predictors of death were age ≥80 years (odds ratio [OR] 8.2, 95{\%} confidence interval [CI] 1.5-43) and heart failure (OR 9.2, 95{\%} CI 3.0-28). Prior stroke/transient ischemic attack/stroke was the only independent predictor for stroke (OR 6.3, 95{\%} CI 3-13).CONCLUSION: In our large population-based study, we found higher procedure-related mortality but comparable stroke rate after AF ABL than previously reported. Age ≥80 years and heart failure was each independently associated with >8-fold increase in odds of death. The only significant predictor of stroke was prior stroke/transient ischemic attack. These findings may aid in patient selection for AF ABL.",
keywords = "Ablation, Atrial fibrillation, Mortality, Stroke",
author = "Srivatsa, {Uma N} and Beate Danielsen and Ivan Anderson and Amsterdam, {Ezra A} and Pezeshkian, {Nayereh G} and Yingbo Yang and White, {Richard H}",
year = "2014",
month = "11",
day = "1",
doi = "10.1016/j.hrthm.2014.07.017",
language = "English (US)",
volume = "11",
pages = "1898--1903",
journal = "Heart Rhythm",
issn = "1547-5271",
publisher = "Elsevier",
number = "11",

}

TY - JOUR

T1 - Risk predictors of stroke and mortality after ablation for atrial fibrillation

T2 - the California experience 2005-2009

AU - Srivatsa, Uma N

AU - Danielsen, Beate

AU - Anderson, Ivan

AU - Amsterdam, Ezra A

AU - Pezeshkian, Nayereh G

AU - Yang, Yingbo

AU - White, Richard H

PY - 2014/11/1

Y1 - 2014/11/1

N2 - BACKGROUND: Ablation (ABL) is a second-line therapy for the management of atrial fibrillation (AF). Single-center studies have demonstrated the safety and efficacy of ABL; however, the low event rates render it difficult to assess predictors of major adverse events.OBJECTIVE: The purpose of this study was to determine the population-based incidence of data and risk factors for both stroke <30 days and death after AF ABL.METHODS: Patients (n = 6207) identified as having undergone AF ABL between 2005 and 2009 by the California Ambulatory Surgery Database in 97 nonfederal hospitals in California were linked to the California Patient Discharge Database and to a master death registry. Data from these patients were analyzed for primary outcomes of 30-day death and ischemic stroke. Independent risk factors for these end-points were determined.RESULTS: Mean patient age was 61.9 years, and the majority of the patients were men. Thirty-day mortality and stroke after ABL were 0.39% and 0.61%, respectively. Independent predictors of death were age ≥80 years (odds ratio [OR] 8.2, 95% confidence interval [CI] 1.5-43) and heart failure (OR 9.2, 95% CI 3.0-28). Prior stroke/transient ischemic attack/stroke was the only independent predictor for stroke (OR 6.3, 95% CI 3-13).CONCLUSION: In our large population-based study, we found higher procedure-related mortality but comparable stroke rate after AF ABL than previously reported. Age ≥80 years and heart failure was each independently associated with >8-fold increase in odds of death. The only significant predictor of stroke was prior stroke/transient ischemic attack. These findings may aid in patient selection for AF ABL.

AB - BACKGROUND: Ablation (ABL) is a second-line therapy for the management of atrial fibrillation (AF). Single-center studies have demonstrated the safety and efficacy of ABL; however, the low event rates render it difficult to assess predictors of major adverse events.OBJECTIVE: The purpose of this study was to determine the population-based incidence of data and risk factors for both stroke <30 days and death after AF ABL.METHODS: Patients (n = 6207) identified as having undergone AF ABL between 2005 and 2009 by the California Ambulatory Surgery Database in 97 nonfederal hospitals in California were linked to the California Patient Discharge Database and to a master death registry. Data from these patients were analyzed for primary outcomes of 30-day death and ischemic stroke. Independent risk factors for these end-points were determined.RESULTS: Mean patient age was 61.9 years, and the majority of the patients were men. Thirty-day mortality and stroke after ABL were 0.39% and 0.61%, respectively. Independent predictors of death were age ≥80 years (odds ratio [OR] 8.2, 95% confidence interval [CI] 1.5-43) and heart failure (OR 9.2, 95% CI 3.0-28). Prior stroke/transient ischemic attack/stroke was the only independent predictor for stroke (OR 6.3, 95% CI 3-13).CONCLUSION: In our large population-based study, we found higher procedure-related mortality but comparable stroke rate after AF ABL than previously reported. Age ≥80 years and heart failure was each independently associated with >8-fold increase in odds of death. The only significant predictor of stroke was prior stroke/transient ischemic attack. These findings may aid in patient selection for AF ABL.

KW - Ablation

KW - Atrial fibrillation

KW - Mortality

KW - Stroke

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U2 - 10.1016/j.hrthm.2014.07.017

DO - 10.1016/j.hrthm.2014.07.017

M3 - Article

VL - 11

SP - 1898

EP - 1903

JO - Heart Rhythm

JF - Heart Rhythm

SN - 1547-5271

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ER -