Risk of Zika microcephaly correlates with features of maternal antibodies

Davide F. Robbiani, Priscilla C. Olsen, Federico Costa, Qiao Wang, Thiago Y. Oliveira, Nivison Nery, Adeolu Aromolaran, Mateus S. do Rosário, Gielson A. Sacramento, Jaqueline S. Cruz, Ricardo Khouri, Elsio A. Wunder, Adriana Mattos, Bruno de Paula Freitas, Manoel Sarno, Gracinda Archanjo, Dina Daltro, Gustavo B.S. Carvalho, Kleber Pimentel, Isadora C. de SiqueiraJoão R.M. de Almeida, Daniele F. Henriques, Juliana A. Lima, Pedro F.C. Vasconcelos, Dennis Schaefer-Babajew, Stephanie A. Azzopardi, Leonia Bozzacco, Anna Gazumyan, Rubens Belfort, Ana P. Alcântara, Gustavo Carvalho, Licia Moreira, Katiaci Araujo, Mitermayer G. Reis, Rebekah I. Keesler, Lark L. Coffey, Jennifer Tisoncik-Go, Michael Gale, Lakshmi Rajagopal, Kristina M. Adams Waldorf, Dawn M. Dudley, Heather A. Simmons, Andres Mejia, David H. O'Connor, Rosemary J. Steinbach, Nicole Haese, Jessica Smith, Anne Lewis, Lois Colgin, Victoria Roberts, Antonio Frias, Meredith Kelleher, Alec Hirsch, Daniel N. Streblow, Charles M. Rice, Margaret R. MacDonald, Antonio R.P. de Almeida, Koen K.A. Van Rompay, Albert I. Ko, Michel C. Nussenzweig

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Zika virus (ZIKV) infection during pregnancy causes congenital abnormalities, including microcephaly. However, rates vary widely, and the contributing risk factors remain unclear. We examined the serum antibody response to ZIKV and other flaviviruses in Brazilian women giving birth during the 2015-2016 outbreak. Infected pregnancies with intermediate or higher ZIKV antibody enhancement titers were at increased risk to give birth to microcephalic infants compared with those with lower titers (P < 0.0001). Similarly, analysis of ZIKV-infected pregnant macaques revealed that fetal brain damage was more frequent in mothers with higher enhancement titers. Thus, features of the maternal antibodies are associated with and may contribute to the genesis of ZIKV-associated microcephaly.

Original languageEnglish (US)
Pages (from-to)2302-2315
Number of pages14
JournalThe Journal of experimental medicine
Volume216
Issue number10
DOIs
StatePublished - Oct 7 2019

Fingerprint

Microcephaly
Mothers
Antibodies
Parturition
Flavivirus
Pregnancy
Macaca
Antibody Formation
Disease Outbreaks
Zika Virus
Brain
Serum

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Robbiani, D. F., Olsen, P. C., Costa, F., Wang, Q., Oliveira, T. Y., Nery, N., ... Nussenzweig, M. C. (2019). Risk of Zika microcephaly correlates with features of maternal antibodies. The Journal of experimental medicine, 216(10), 2302-2315. https://doi.org/10.1084/jem.20191061

Risk of Zika microcephaly correlates with features of maternal antibodies. / Robbiani, Davide F.; Olsen, Priscilla C.; Costa, Federico; Wang, Qiao; Oliveira, Thiago Y.; Nery, Nivison; Aromolaran, Adeolu; do Rosário, Mateus S.; Sacramento, Gielson A.; Cruz, Jaqueline S.; Khouri, Ricardo; Wunder, Elsio A.; Mattos, Adriana; de Paula Freitas, Bruno; Sarno, Manoel; Archanjo, Gracinda; Daltro, Dina; Carvalho, Gustavo B.S.; Pimentel, Kleber; de Siqueira, Isadora C.; de Almeida, João R.M.; Henriques, Daniele F.; Lima, Juliana A.; Vasconcelos, Pedro F.C.; Schaefer-Babajew, Dennis; Azzopardi, Stephanie A.; Bozzacco, Leonia; Gazumyan, Anna; Belfort, Rubens; Alcântara, Ana P.; Carvalho, Gustavo; Moreira, Licia; Araujo, Katiaci; Reis, Mitermayer G.; Keesler, Rebekah I.; Coffey, Lark L.; Tisoncik-Go, Jennifer; Gale, Michael; Rajagopal, Lakshmi; Adams Waldorf, Kristina M.; Dudley, Dawn M.; Simmons, Heather A.; Mejia, Andres; O'Connor, David H.; Steinbach, Rosemary J.; Haese, Nicole; Smith, Jessica; Lewis, Anne; Colgin, Lois; Roberts, Victoria; Frias, Antonio; Kelleher, Meredith; Hirsch, Alec; Streblow, Daniel N.; Rice, Charles M.; MacDonald, Margaret R.; de Almeida, Antonio R.P.; Van Rompay, Koen K.A.; Ko, Albert I.; Nussenzweig, Michel C.

In: The Journal of experimental medicine, Vol. 216, No. 10, 07.10.2019, p. 2302-2315.

Research output: Contribution to journalArticle

Robbiani, DF, Olsen, PC, Costa, F, Wang, Q, Oliveira, TY, Nery, N, Aromolaran, A, do Rosário, MS, Sacramento, GA, Cruz, JS, Khouri, R, Wunder, EA, Mattos, A, de Paula Freitas, B, Sarno, M, Archanjo, G, Daltro, D, Carvalho, GBS, Pimentel, K, de Siqueira, IC, de Almeida, JRM, Henriques, DF, Lima, JA, Vasconcelos, PFC, Schaefer-Babajew, D, Azzopardi, SA, Bozzacco, L, Gazumyan, A, Belfort, R, Alcântara, AP, Carvalho, G, Moreira, L, Araujo, K, Reis, MG, Keesler, RI, Coffey, LL, Tisoncik-Go, J, Gale, M, Rajagopal, L, Adams Waldorf, KM, Dudley, DM, Simmons, HA, Mejia, A, O'Connor, DH, Steinbach, RJ, Haese, N, Smith, J, Lewis, A, Colgin, L, Roberts, V, Frias, A, Kelleher, M, Hirsch, A, Streblow, DN, Rice, CM, MacDonald, MR, de Almeida, ARP, Van Rompay, KKA, Ko, AI & Nussenzweig, MC 2019, 'Risk of Zika microcephaly correlates with features of maternal antibodies', The Journal of experimental medicine, vol. 216, no. 10, pp. 2302-2315. https://doi.org/10.1084/jem.20191061
Robbiani DF, Olsen PC, Costa F, Wang Q, Oliveira TY, Nery N et al. Risk of Zika microcephaly correlates with features of maternal antibodies. The Journal of experimental medicine. 2019 Oct 7;216(10):2302-2315. https://doi.org/10.1084/jem.20191061
Robbiani, Davide F. ; Olsen, Priscilla C. ; Costa, Federico ; Wang, Qiao ; Oliveira, Thiago Y. ; Nery, Nivison ; Aromolaran, Adeolu ; do Rosário, Mateus S. ; Sacramento, Gielson A. ; Cruz, Jaqueline S. ; Khouri, Ricardo ; Wunder, Elsio A. ; Mattos, Adriana ; de Paula Freitas, Bruno ; Sarno, Manoel ; Archanjo, Gracinda ; Daltro, Dina ; Carvalho, Gustavo B.S. ; Pimentel, Kleber ; de Siqueira, Isadora C. ; de Almeida, João R.M. ; Henriques, Daniele F. ; Lima, Juliana A. ; Vasconcelos, Pedro F.C. ; Schaefer-Babajew, Dennis ; Azzopardi, Stephanie A. ; Bozzacco, Leonia ; Gazumyan, Anna ; Belfort, Rubens ; Alcântara, Ana P. ; Carvalho, Gustavo ; Moreira, Licia ; Araujo, Katiaci ; Reis, Mitermayer G. ; Keesler, Rebekah I. ; Coffey, Lark L. ; Tisoncik-Go, Jennifer ; Gale, Michael ; Rajagopal, Lakshmi ; Adams Waldorf, Kristina M. ; Dudley, Dawn M. ; Simmons, Heather A. ; Mejia, Andres ; O'Connor, David H. ; Steinbach, Rosemary J. ; Haese, Nicole ; Smith, Jessica ; Lewis, Anne ; Colgin, Lois ; Roberts, Victoria ; Frias, Antonio ; Kelleher, Meredith ; Hirsch, Alec ; Streblow, Daniel N. ; Rice, Charles M. ; MacDonald, Margaret R. ; de Almeida, Antonio R.P. ; Van Rompay, Koen K.A. ; Ko, Albert I. ; Nussenzweig, Michel C. / Risk of Zika microcephaly correlates with features of maternal antibodies. In: The Journal of experimental medicine. 2019 ; Vol. 216, No. 10. pp. 2302-2315.
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abstract = "Zika virus (ZIKV) infection during pregnancy causes congenital abnormalities, including microcephaly. However, rates vary widely, and the contributing risk factors remain unclear. We examined the serum antibody response to ZIKV and other flaviviruses in Brazilian women giving birth during the 2015-2016 outbreak. Infected pregnancies with intermediate or higher ZIKV antibody enhancement titers were at increased risk to give birth to microcephalic infants compared with those with lower titers (P < 0.0001). Similarly, analysis of ZIKV-infected pregnant macaques revealed that fetal brain damage was more frequent in mothers with higher enhancement titers. Thus, features of the maternal antibodies are associated with and may contribute to the genesis of ZIKV-associated microcephaly.",
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AU - Robbiani, Davide F.

AU - Olsen, Priscilla C.

AU - Costa, Federico

AU - Wang, Qiao

AU - Oliveira, Thiago Y.

AU - Nery, Nivison

AU - Aromolaran, Adeolu

AU - do Rosário, Mateus S.

AU - Sacramento, Gielson A.

AU - Cruz, Jaqueline S.

AU - Khouri, Ricardo

AU - Wunder, Elsio A.

AU - Mattos, Adriana

AU - de Paula Freitas, Bruno

AU - Sarno, Manoel

AU - Archanjo, Gracinda

AU - Daltro, Dina

AU - Carvalho, Gustavo B.S.

AU - Pimentel, Kleber

AU - de Siqueira, Isadora C.

AU - de Almeida, João R.M.

AU - Henriques, Daniele F.

AU - Lima, Juliana A.

AU - Vasconcelos, Pedro F.C.

AU - Schaefer-Babajew, Dennis

AU - Azzopardi, Stephanie A.

AU - Bozzacco, Leonia

AU - Gazumyan, Anna

AU - Belfort, Rubens

AU - Alcântara, Ana P.

AU - Carvalho, Gustavo

AU - Moreira, Licia

AU - Araujo, Katiaci

AU - Reis, Mitermayer G.

AU - Keesler, Rebekah I.

AU - Coffey, Lark L.

AU - Tisoncik-Go, Jennifer

AU - Gale, Michael

AU - Rajagopal, Lakshmi

AU - Adams Waldorf, Kristina M.

AU - Dudley, Dawn M.

AU - Simmons, Heather A.

AU - Mejia, Andres

AU - O'Connor, David H.

AU - Steinbach, Rosemary J.

AU - Haese, Nicole

AU - Smith, Jessica

AU - Lewis, Anne

AU - Colgin, Lois

AU - Roberts, Victoria

AU - Frias, Antonio

AU - Kelleher, Meredith

AU - Hirsch, Alec

AU - Streblow, Daniel N.

AU - Rice, Charles M.

AU - MacDonald, Margaret R.

AU - de Almeida, Antonio R.P.

AU - Van Rompay, Koen K.A.

AU - Ko, Albert I.

AU - Nussenzweig, Michel C.

PY - 2019/10/7

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