Risk of second primary cutaneous and noncutaneous melanoma after cutaneous melanoma diagnosis: A population-based study

Kourosh Beroukhim, Aunna Pourang, Daniel B. Eisen

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Background: While cutaneous melanomas (CM) account for greater than 90% of all melanomas, noncutaneous melanomas (NCM) are more aggressive and associated with worse outcomes. The shared progenitor cell type among CM and NCM suggests that patients with a history of CM may be at higher risk for subsequent NCM. Objective: To determine whether patients with a history of CM demonstrate an increased risk of second primary cutaneous, ocular, oral, or vaginal/exocervical melanoma compared with the general population. Methods: This was a population-based retrospective cohort study using the Surveillance, Epidemiology, and End Results database. We calculated standardized incidence ratios (SIRs) and excess absolute risks of second primary cutaneous, ocular, oral, and vaginal/exocervical melanoma in patients with a history of CM. Results: Patients with prior CM (n = 169,841) were more likely than the general population to develop a second primary CM (SIR, 8.17; 95% confidence interval [CI], 8.01-8.33), ocular melanoma (SIR, 1.99; 95% CI, 1.54-2.53), oral melanoma (SIR, 6.87; 95% CI, 2.23-16.04), and vaginal/exocervical melanoma (SIR, 10.17; 95% CI, 4.65-19.30). Limitations: This study is limited by possible under-reporting of CM in cancer registries. Conclusion: In caring for patients with a history of CM, physicians should be vigilant not only about risk of recurrence but also about second primary CM and NCM.

Original languageEnglish (US)
Pages (from-to)683-689
Number of pages7
JournalJournal of the American Academy of Dermatology
Volume82
Issue number3
DOIs
StatePublished - Mar 2020

Keywords

  • and End Results program
  • cutaneous melanoma
  • Epidemiology
  • melanoma
  • noncutaneous melanoma
  • screening
  • second primary melanoma
  • Surveillance

ASJC Scopus subject areas

  • Dermatology

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