Abstract
Objective - To estimate risk of exposure and age at first exposure to Sarcocystis neurona and Neospora hughesi and time to maternal antibody decay in foals. Animals - 484 Thoroughbred and Warmblood foals from 4 farms in California. Procedure - Serum was collected before and after colostrum ingestion and at 3-month intervals thereafter. Samples were tested by use of the indirect fluorescent antibody test; cutoff titers were ≥ 40 and ≥ 160 for S neurona and N hughesi, respectively. Results - Risk of exposure to S neurona and N hughesi during the study were 8.2% and 3.1%, respectively. Annual rate of exposure was 3.1% for S neurona and 1.7% for N hughesi. There was a significant difference in the risk of exposure to S neurona among farms but not in the risk of exposure to N hughesi. Median age at first exposure was 1.2 years for S neurona and 0.8 years for N hughesi. Highest prevalence of antibodies against S neurona and N hughesi was 6% and 2.1%, respectively, at a aman age of 1.7 and 1.4 years, respectively. Median time to maternal antibody decay was 96 days for S neurona and 91 days for N hughesi. There were no clinical cases of equine protozoal myeloenchaphlitis (EPM). Conclusions and Clinical Relevance - Exposure to S neurona and N hughesi was low in foals between birth and 2.5 years of age. Maternally acquired antibodies may cause false-positive results for 3 or 4 months after birth, and EPM was a rare clinical disease in horses ≤ 2.5 years of age.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1047-1052 |
| Number of pages | 6 |
| Journal | American Journal of Veterinary Research |
| Volume | 65 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 2004 |
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Risk of postnatal exposure to Sarcocystis neurona and Neospora hughesi in horses. / Duarte, Paulo de C; Conrad, Patricia A; Wilson, William D; Ferraro, Gregory L.; Packham, Andrea E.; Bowers-Lepore, Jeanne; Carpenter, Tim; Gardner, Ian.
In: American Journal of Veterinary Research, Vol. 65, No. 8, 08.2004, p. 1047-1052.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Risk of postnatal exposure to Sarcocystis neurona and Neospora hughesi in horses
AU - Duarte, Paulo de C
AU - Conrad, Patricia A
AU - Wilson, William D
AU - Ferraro, Gregory L.
AU - Packham, Andrea E.
AU - Bowers-Lepore, Jeanne
AU - Carpenter, Tim
AU - Gardner, Ian
PY - 2004/8
Y1 - 2004/8
N2 - Objective - To estimate risk of exposure and age at first exposure to Sarcocystis neurona and Neospora hughesi and time to maternal antibody decay in foals. Animals - 484 Thoroughbred and Warmblood foals from 4 farms in California. Procedure - Serum was collected before and after colostrum ingestion and at 3-month intervals thereafter. Samples were tested by use of the indirect fluorescent antibody test; cutoff titers were ≥ 40 and ≥ 160 for S neurona and N hughesi, respectively. Results - Risk of exposure to S neurona and N hughesi during the study were 8.2% and 3.1%, respectively. Annual rate of exposure was 3.1% for S neurona and 1.7% for N hughesi. There was a significant difference in the risk of exposure to S neurona among farms but not in the risk of exposure to N hughesi. Median age at first exposure was 1.2 years for S neurona and 0.8 years for N hughesi. Highest prevalence of antibodies against S neurona and N hughesi was 6% and 2.1%, respectively, at a aman age of 1.7 and 1.4 years, respectively. Median time to maternal antibody decay was 96 days for S neurona and 91 days for N hughesi. There were no clinical cases of equine protozoal myeloenchaphlitis (EPM). Conclusions and Clinical Relevance - Exposure to S neurona and N hughesi was low in foals between birth and 2.5 years of age. Maternally acquired antibodies may cause false-positive results for 3 or 4 months after birth, and EPM was a rare clinical disease in horses ≤ 2.5 years of age.
AB - Objective - To estimate risk of exposure and age at first exposure to Sarcocystis neurona and Neospora hughesi and time to maternal antibody decay in foals. Animals - 484 Thoroughbred and Warmblood foals from 4 farms in California. Procedure - Serum was collected before and after colostrum ingestion and at 3-month intervals thereafter. Samples were tested by use of the indirect fluorescent antibody test; cutoff titers were ≥ 40 and ≥ 160 for S neurona and N hughesi, respectively. Results - Risk of exposure to S neurona and N hughesi during the study were 8.2% and 3.1%, respectively. Annual rate of exposure was 3.1% for S neurona and 1.7% for N hughesi. There was a significant difference in the risk of exposure to S neurona among farms but not in the risk of exposure to N hughesi. Median age at first exposure was 1.2 years for S neurona and 0.8 years for N hughesi. Highest prevalence of antibodies against S neurona and N hughesi was 6% and 2.1%, respectively, at a aman age of 1.7 and 1.4 years, respectively. Median time to maternal antibody decay was 96 days for S neurona and 91 days for N hughesi. There were no clinical cases of equine protozoal myeloenchaphlitis (EPM). Conclusions and Clinical Relevance - Exposure to S neurona and N hughesi was low in foals between birth and 2.5 years of age. Maternally acquired antibodies may cause false-positive results for 3 or 4 months after birth, and EPM was a rare clinical disease in horses ≤ 2.5 years of age.
UR - http://www.scopus.com/inward/record.url?scp=4344611750&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=4344611750&partnerID=8YFLogxK
U2 - 10.2460/ajvr.2004.65.1047
DO - 10.2460/ajvr.2004.65.1047
M3 - Article
C2 - 15334837
AN - SCOPUS:4344611750
VL - 65
SP - 1047
EP - 1052
JO - American Journal of Veterinary Research
JF - American Journal of Veterinary Research
SN - 0002-9645
IS - 8
ER -