Risk of cardiovascular events after infection-related hospitalizations in older patients on dialysis

Lorien Dalrymple, Sandra M. Mohammed, Yi Mu, Kirsten L. Johansen, Glenn M. Chertow, Barbara Grimes, George Kaysen, Danh V. Nguyen

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Background and objectives Infection and cardiovascular disease are leading causes of hospitalization and death in patients on dialysis. The objective of this study was to determine whether an infection-related hospitalization increased the short-term risk of a cardiovascular event in older patients on dialysis. Design, setting, participants, & measurements With use of the United States Renal Data System, patients aged 65 to 100 years who started dialysis between January 1, 2000, and December 31, 2002, were examined. All hospitalizations were examined from study entry until time of transplant, death, or December 31, 2004. All discharge diagnoses were examined to determine if an infection occurred during hospitalization. Only principal discharge diagnoses were examined to ascertain cardiovascular events of interest. We used the self-controlled case-series method to estimate the relative incidence of a cardiovascular event within 90 days after an infection-related hospitalization as compared with other times not within 90 days of such a hospitalization. Results A total of 16,874 patients had at least one cardiovascular event and were included in the self-controlled case-series analysis. The risk of a cardiovascular event was increased by 25% in the first 30 days after an infection and was overall increased 18% in the 90 days after an infection-related hospitalization relative to control periods. Conclusions The first 90 days, and in particular the first 30 days, after an infection-related hospitalization is a high-risk period for cardiovascular events and may be an important timeframe for cardiovascular risk reduction, monitoring, and intervention in older patients on dialysis.

Original languageEnglish (US)
Pages (from-to)1708-1713
Number of pages6
JournalClinical Journal of the American Society of Nephrology
Volume6
Issue number7
DOIs
StatePublished - Jul 1 2011

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Dialysis
Hospitalization
Infection
Risk Reduction Behavior
Information Systems
Cause of Death
Cardiovascular Diseases
Transplants
Kidney
Incidence

ASJC Scopus subject areas

  • Nephrology
  • Transplantation
  • Epidemiology
  • Critical Care and Intensive Care Medicine

Cite this

Dalrymple, L., Mohammed, S. M., Mu, Y., Johansen, K. L., Chertow, G. M., Grimes, B., ... Nguyen, D. V. (2011). Risk of cardiovascular events after infection-related hospitalizations in older patients on dialysis. Clinical Journal of the American Society of Nephrology, 6(7), 1708-1713. https://doi.org/10.2215/CJN.10151110

Risk of cardiovascular events after infection-related hospitalizations in older patients on dialysis. / Dalrymple, Lorien; Mohammed, Sandra M.; Mu, Yi; Johansen, Kirsten L.; Chertow, Glenn M.; Grimes, Barbara; Kaysen, George; Nguyen, Danh V.

In: Clinical Journal of the American Society of Nephrology, Vol. 6, No. 7, 01.07.2011, p. 1708-1713.

Research output: Contribution to journalArticle

Dalrymple, Lorien ; Mohammed, Sandra M. ; Mu, Yi ; Johansen, Kirsten L. ; Chertow, Glenn M. ; Grimes, Barbara ; Kaysen, George ; Nguyen, Danh V. / Risk of cardiovascular events after infection-related hospitalizations in older patients on dialysis. In: Clinical Journal of the American Society of Nephrology. 2011 ; Vol. 6, No. 7. pp. 1708-1713.
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