Risk of breast, endometrial, colorectal, and renal cancers in postmenopausal women in association with a body shape index and other anthropometric measures

Geoffrey C. Kabat, Xiaonan Xue, Victor Kamensky, Dorothy Lane, Jennifer W. Bea, Chu Chen, Lihong Qi, Marcia L. Stefanick, Rowan T. Chlebowski, Jean Wactawski-Wende, Sylvia Wassertheil-Smoller, Thomas E. Rohan

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Abstract

Purpose: A body shape index (ABSI) has been proposed as a possible improvement over waist circumference (WC) as a marker of abdominal adiposity because it removes the correlation of WC with body mass index (BMI) and with height. We assessed the association of ABSI with four obesity-related cancers compared to that of other anthropometric measures of adiposity. Methods: We used data from the Women’s Health Initiative, a large cohort of postmenopausal women, recruited between 1993 and 1998 and followed until September 2013, to assess the associations of ABSI and other anthropometric measures with risk of cancers of the breast, endometrium, colorectum, and kidney. The four comparison anthropometric measures were BMI, WC, waist circumference-to-height ratio (WHtR), and waist-hip ratio (WHR). Over a median of 12.7 years of follow-up, among 143,901 women, we identified 7,039 invasive breast cancers, 1,157 endometrial cancers, 1,908 colorectal cancers, and 376 kidney cancers. We used Cox proportional hazards models to estimate the association of quintiles of the five measures with risk of the four cancers. Results: Unlike the other anthropometric indices, ABSI was not associated with increased risk of breast or endometrial cancer. BMI and WC were comparable as predictors of breast and endometrial cancer, and these associations were unchanged after mutual adjustment. For colorectal and kidney cancers, ABSI was a significant predictor comparable to BMI; however, WC showed the strongest association with colorectal cancer, and WC, WHtR, and WHR all showed stronger associations with kidney cancer. Conclusion: In contrast to other anthropometric measures, ABSI showed no association with risk of breast or endometrial cancer and was more weakly associated with risk of colorectal and kidney cancers compared to more established measures of central adiposity.

Original languageEnglish (US)
Pages (from-to)219-229
Number of pages11
JournalCancer Causes and Control
Volume26
Issue number2
DOIs
StatePublished - 2014

Fingerprint

Kidney Neoplasms
Waist Circumference
Endometrial Neoplasms
Colorectal Neoplasms
Breast Neoplasms
Adiposity
Body Mass Index
Waist-Hip Ratio
Body Weights and Measures
Women's Health
Proportional Hazards Models
Neoplasms
Obesity
Kidney

Keywords

  • Body mass index
  • Body shape index
  • Cancer
  • Obesity
  • Waist circumference

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Risk of breast, endometrial, colorectal, and renal cancers in postmenopausal women in association with a body shape index and other anthropometric measures. / Kabat, Geoffrey C.; Xue, Xiaonan; Kamensky, Victor; Lane, Dorothy; Bea, Jennifer W.; Chen, Chu; Qi, Lihong; Stefanick, Marcia L.; Chlebowski, Rowan T.; Wactawski-Wende, Jean; Wassertheil-Smoller, Sylvia; Rohan, Thomas E.

In: Cancer Causes and Control, Vol. 26, No. 2, 2014, p. 219-229.

Research output: Contribution to journalArticle

Kabat, GC, Xue, X, Kamensky, V, Lane, D, Bea, JW, Chen, C, Qi, L, Stefanick, ML, Chlebowski, RT, Wactawski-Wende, J, Wassertheil-Smoller, S & Rohan, TE 2014, 'Risk of breast, endometrial, colorectal, and renal cancers in postmenopausal women in association with a body shape index and other anthropometric measures', Cancer Causes and Control, vol. 26, no. 2, pp. 219-229. https://doi.org/10.1007/s10552-014-0501-4
Kabat, Geoffrey C. ; Xue, Xiaonan ; Kamensky, Victor ; Lane, Dorothy ; Bea, Jennifer W. ; Chen, Chu ; Qi, Lihong ; Stefanick, Marcia L. ; Chlebowski, Rowan T. ; Wactawski-Wende, Jean ; Wassertheil-Smoller, Sylvia ; Rohan, Thomas E. / Risk of breast, endometrial, colorectal, and renal cancers in postmenopausal women in association with a body shape index and other anthropometric measures. In: Cancer Causes and Control. 2014 ; Vol. 26, No. 2. pp. 219-229.
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abstract = "Purpose: A body shape index (ABSI) has been proposed as a possible improvement over waist circumference (WC) as a marker of abdominal adiposity because it removes the correlation of WC with body mass index (BMI) and with height. We assessed the association of ABSI with four obesity-related cancers compared to that of other anthropometric measures of adiposity. Methods: We used data from the Women’s Health Initiative, a large cohort of postmenopausal women, recruited between 1993 and 1998 and followed until September 2013, to assess the associations of ABSI and other anthropometric measures with risk of cancers of the breast, endometrium, colorectum, and kidney. The four comparison anthropometric measures were BMI, WC, waist circumference-to-height ratio (WHtR), and waist-hip ratio (WHR). Over a median of 12.7 years of follow-up, among 143,901 women, we identified 7,039 invasive breast cancers, 1,157 endometrial cancers, 1,908 colorectal cancers, and 376 kidney cancers. We used Cox proportional hazards models to estimate the association of quintiles of the five measures with risk of the four cancers. Results: Unlike the other anthropometric indices, ABSI was not associated with increased risk of breast or endometrial cancer. BMI and WC were comparable as predictors of breast and endometrial cancer, and these associations were unchanged after mutual adjustment. For colorectal and kidney cancers, ABSI was a significant predictor comparable to BMI; however, WC showed the strongest association with colorectal cancer, and WC, WHtR, and WHR all showed stronger associations with kidney cancer. Conclusion: In contrast to other anthropometric measures, ABSI showed no association with risk of breast or endometrial cancer and was more weakly associated with risk of colorectal and kidney cancers compared to more established measures of central adiposity.",
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T1 - Risk of breast, endometrial, colorectal, and renal cancers in postmenopausal women in association with a body shape index and other anthropometric measures

AU - Kabat, Geoffrey C.

AU - Xue, Xiaonan

AU - Kamensky, Victor

AU - Lane, Dorothy

AU - Bea, Jennifer W.

AU - Chen, Chu

AU - Qi, Lihong

AU - Stefanick, Marcia L.

AU - Chlebowski, Rowan T.

AU - Wactawski-Wende, Jean

AU - Wassertheil-Smoller, Sylvia

AU - Rohan, Thomas E.

PY - 2014

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N2 - Purpose: A body shape index (ABSI) has been proposed as a possible improvement over waist circumference (WC) as a marker of abdominal adiposity because it removes the correlation of WC with body mass index (BMI) and with height. We assessed the association of ABSI with four obesity-related cancers compared to that of other anthropometric measures of adiposity. Methods: We used data from the Women’s Health Initiative, a large cohort of postmenopausal women, recruited between 1993 and 1998 and followed until September 2013, to assess the associations of ABSI and other anthropometric measures with risk of cancers of the breast, endometrium, colorectum, and kidney. The four comparison anthropometric measures were BMI, WC, waist circumference-to-height ratio (WHtR), and waist-hip ratio (WHR). Over a median of 12.7 years of follow-up, among 143,901 women, we identified 7,039 invasive breast cancers, 1,157 endometrial cancers, 1,908 colorectal cancers, and 376 kidney cancers. We used Cox proportional hazards models to estimate the association of quintiles of the five measures with risk of the four cancers. Results: Unlike the other anthropometric indices, ABSI was not associated with increased risk of breast or endometrial cancer. BMI and WC were comparable as predictors of breast and endometrial cancer, and these associations were unchanged after mutual adjustment. For colorectal and kidney cancers, ABSI was a significant predictor comparable to BMI; however, WC showed the strongest association with colorectal cancer, and WC, WHtR, and WHR all showed stronger associations with kidney cancer. Conclusion: In contrast to other anthropometric measures, ABSI showed no association with risk of breast or endometrial cancer and was more weakly associated with risk of colorectal and kidney cancers compared to more established measures of central adiposity.

AB - Purpose: A body shape index (ABSI) has been proposed as a possible improvement over waist circumference (WC) as a marker of abdominal adiposity because it removes the correlation of WC with body mass index (BMI) and with height. We assessed the association of ABSI with four obesity-related cancers compared to that of other anthropometric measures of adiposity. Methods: We used data from the Women’s Health Initiative, a large cohort of postmenopausal women, recruited between 1993 and 1998 and followed until September 2013, to assess the associations of ABSI and other anthropometric measures with risk of cancers of the breast, endometrium, colorectum, and kidney. The four comparison anthropometric measures were BMI, WC, waist circumference-to-height ratio (WHtR), and waist-hip ratio (WHR). Over a median of 12.7 years of follow-up, among 143,901 women, we identified 7,039 invasive breast cancers, 1,157 endometrial cancers, 1,908 colorectal cancers, and 376 kidney cancers. We used Cox proportional hazards models to estimate the association of quintiles of the five measures with risk of the four cancers. Results: Unlike the other anthropometric indices, ABSI was not associated with increased risk of breast or endometrial cancer. BMI and WC were comparable as predictors of breast and endometrial cancer, and these associations were unchanged after mutual adjustment. For colorectal and kidney cancers, ABSI was a significant predictor comparable to BMI; however, WC showed the strongest association with colorectal cancer, and WC, WHtR, and WHR all showed stronger associations with kidney cancer. Conclusion: In contrast to other anthropometric measures, ABSI showed no association with risk of breast or endometrial cancer and was more weakly associated with risk of colorectal and kidney cancers compared to more established measures of central adiposity.

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KW - Obesity

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