Abstract
This case-control study of proximal humerus fracture included 448 incident female and male cases and 2,023 controls aged 45 years or older identified in five Northern California Kaiser Permanente Medical Centers in 1996-2001. Data were collected by using an interviewer-administered questionnaire. Some factors related to low bone mass, including number of fractures since age 45 years and low dietary calcium intake, were associated with increased risks of fracture, and factors thought to protect against bone loss, such as menopausal hormone therapy and calcium carbonate tablet use, were associated with reduced risks. Fall-related risk factors included previous falls, diabetes melliltus, and difficulty walking in dim light. Possible fall-related risk factors suggested for the first time in this study were seizure medication use (adjusted odds ratio (OR) = 2.80, 95% confidence interval (CI): 1.45, 5.42), depression (OR = 1.34, 95% CI: 0.98, 1.84), almost always using a hearing aid (OR = 1.92, 95% CI: 1.12, 3.31 vs. never prescribed), and left-handedness (OR = 2.36, 95% CI: 1.51, 3.68 vs. right-handedness). Difficulty with activities of daily living and lack of physical activity tended to be associated with increased risk. Prevention of falls among frail, osteoporotic persons would likely reduce the frequency of proximal humerus fracture.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 360-367 |
| Number of pages | 8 |
| Journal | American Journal of Epidemiology |
| Volume | 160 |
| Issue number | 4 |
| DOIs | |
| State | Published - Aug 15 2004 |
| Externally published | Yes |
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Keywords
- Accidental falls
- Estrogen replacement therapy
- Fractures
- Humerus
- Laterality
- Motor activity
- Pharmaceutical preparations
ASJC Scopus subject areas
- Epidemiology
Cite this
Risk factors for proximal humerus fracture. / Chu, Sarah P.; Kelsey, Jennifer L.; Keegan, Theresa H; Sternfeld, Barbara; Prill, Mila; Quesenberry, Charles P.; Sidney, Stephen.
In: American Journal of Epidemiology, Vol. 160, No. 4, 15.08.2004, p. 360-367.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Risk factors for proximal humerus fracture
AU - Chu, Sarah P.
AU - Kelsey, Jennifer L.
AU - Keegan, Theresa H
AU - Sternfeld, Barbara
AU - Prill, Mila
AU - Quesenberry, Charles P.
AU - Sidney, Stephen
PY - 2004/8/15
Y1 - 2004/8/15
N2 - This case-control study of proximal humerus fracture included 448 incident female and male cases and 2,023 controls aged 45 years or older identified in five Northern California Kaiser Permanente Medical Centers in 1996-2001. Data were collected by using an interviewer-administered questionnaire. Some factors related to low bone mass, including number of fractures since age 45 years and low dietary calcium intake, were associated with increased risks of fracture, and factors thought to protect against bone loss, such as menopausal hormone therapy and calcium carbonate tablet use, were associated with reduced risks. Fall-related risk factors included previous falls, diabetes melliltus, and difficulty walking in dim light. Possible fall-related risk factors suggested for the first time in this study were seizure medication use (adjusted odds ratio (OR) = 2.80, 95% confidence interval (CI): 1.45, 5.42), depression (OR = 1.34, 95% CI: 0.98, 1.84), almost always using a hearing aid (OR = 1.92, 95% CI: 1.12, 3.31 vs. never prescribed), and left-handedness (OR = 2.36, 95% CI: 1.51, 3.68 vs. right-handedness). Difficulty with activities of daily living and lack of physical activity tended to be associated with increased risk. Prevention of falls among frail, osteoporotic persons would likely reduce the frequency of proximal humerus fracture.
AB - This case-control study of proximal humerus fracture included 448 incident female and male cases and 2,023 controls aged 45 years or older identified in five Northern California Kaiser Permanente Medical Centers in 1996-2001. Data were collected by using an interviewer-administered questionnaire. Some factors related to low bone mass, including number of fractures since age 45 years and low dietary calcium intake, were associated with increased risks of fracture, and factors thought to protect against bone loss, such as menopausal hormone therapy and calcium carbonate tablet use, were associated with reduced risks. Fall-related risk factors included previous falls, diabetes melliltus, and difficulty walking in dim light. Possible fall-related risk factors suggested for the first time in this study were seizure medication use (adjusted odds ratio (OR) = 2.80, 95% confidence interval (CI): 1.45, 5.42), depression (OR = 1.34, 95% CI: 0.98, 1.84), almost always using a hearing aid (OR = 1.92, 95% CI: 1.12, 3.31 vs. never prescribed), and left-handedness (OR = 2.36, 95% CI: 1.51, 3.68 vs. right-handedness). Difficulty with activities of daily living and lack of physical activity tended to be associated with increased risk. Prevention of falls among frail, osteoporotic persons would likely reduce the frequency of proximal humerus fracture.
KW - Accidental falls
KW - Estrogen replacement therapy
KW - Fractures
KW - Humerus
KW - Laterality
KW - Motor activity
KW - Pharmaceutical preparations
UR - http://www.scopus.com/inward/record.url?scp=3843085400&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=3843085400&partnerID=8YFLogxK
U2 - 10.1093/aje/kwh224
DO - 10.1093/aje/kwh224
M3 - Article
C2 - 15286021
AN - SCOPUS:3843085400
VL - 160
SP - 360
EP - 367
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
SN - 0002-9262
IS - 4
ER -