Risk factors for early repeat ERCP in liver transplantation patients with anastomotic biliary stricture

James H. Tabibian, Mohit Girotra, Hsin Chieh Yeh, Vikesh K. Singh, Patrick I. Okolo, Andrew M. Cameron, Ahmet Gurakar

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Introduction. Anastomotic biliary strictures (ABS) are a significant clinical problem associated with decreased survival post-liver transplantation (LT). Contributing to the morbidity of ABS is the need for early (i.e. emergent or unplanned) repeat endoscopic retrograde cholangiopancreatographies (ER-ERCPs). Our aim was to determine clinical, operative, and endoscopic predictors of ER-ERCP in patients with ABS. Material and methods. Medical records of 559 patients who underwent LT at our institution from 2000-2012 were retrospectively reviewed for pertinent data. The primary endpoint was need for ER-ERCP. Seventeen potential predictors of ER-ERCP were assessed in bivariate analyses, and those with p < 0.20 were included in multivariate regression models. Results. Fifty-four LT patients developed ABS and underwent a total of 200 ERCPs, of which 40 met criteria for ER-ERCP. Predictors of ER-ERCP in bivariate analyses included balloon dilation within 3 months post-LT and donation after cardiac death (both p < 0.05). Balloon dilation within 3 months post-LT was also associated with shorter ER-ERCP-free survival (p = 0.02). Moreover, a significantly higher proportion (67%) of patients who underwent balloon dilation within 3 months post-LT subsequent experienced ≥ 1 ER-ERCP (p = 0.03), and those who experienced ≥ 1 ER-ERCP had lower stricture resolution rates at the end of endoscopic therapy compared to those who did not (79 vs. 97%, p = 0.02). In multivariate analyses, balloon dilation within 3 months post-LT was the strongest predictor of ER-ERCP (OR 3.8, 95% CI 1.7-8.6, p = 0.001). Conclusions. Balloon dilation of ABS within 3 months post-LT is associated with an increased risk of ER-ERCP, which itself is associated with lower ABS resolution rates. Prospective studies are needed to confirm these findings and their implications for endoscopic management and follow-up of post-LT ABS.

Original languageEnglish (US)
Pages (from-to)340-347
Number of pages8
JournalAnnals of Hepatology
Volume14
Issue number3
StatePublished - 2015
Externally publishedYes

Keywords

  • Balloon dilation
  • Bile duct disease
  • Biliary obstruction
  • Endoscopic therapy
  • Stents

ASJC Scopus subject areas

  • Hepatology
  • Medicine(all)

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    Tabibian, J. H., Girotra, M., Yeh, H. C., Singh, V. K., Okolo, P. I., Cameron, A. M., & Gurakar, A. (2015). Risk factors for early repeat ERCP in liver transplantation patients with anastomotic biliary stricture. Annals of Hepatology, 14(3), 340-347.