Risk factors for bacterial zoonotic pathogens in acutely febrile patients in Mpumalanga Province, South Africa

Amanda M. Berrian, Beatriz Martinez Lopez, Vanessa Quan, Patricia A Conrad, Jacques van Rooyen, Gregory J.G. Simpson, John Frean, Jacqueline Weyer, Jennifer Rossouw, Darryn Knobel, Lucille Blumberg

Research output: Contribution to journalArticle

Abstract

Endemic zoonoses, such as Q fever and spotted fever group (SFG) rickettsiosis, are prevalent in South Africa, yet often undiagnosed. In this study, we reviewed the demographics and animal exposure history of patients presenting with acute febrile illness to community health clinics in Mpumalanga Province to identify trends and risk factors associated with exposure to Coxiella burnetii, the causative agent of Q fever, and infection by SFG Rickettsia spp. Clinical and serological data and questionnaires elucidating exposure to animals and their products were obtained from 141 acutely febrile patients between 2012 and 2016. Exposure or infection status to C. burnetii and SFG Rickettsia spp. was determined by presence of IgG or IgM antibodies. Logistic regression models were built for risk factor analysis. Clinical presentation of patients infected by SFG rickettsiosis was described. There were 37/139 (27%) patients with a positive C. burnetii serology, indicative of Q fever exposure. Patients who had reported attending cattle inspection facilities (“dip tanks”) were 9.39 times more likely to be exposed to Q fever (95% CI: 2.9–30.4). Exposure risk also increased with age (OR: 1.03, 95% CI: 1.002–1.06). Twenty-one per cent of febrile patients (24/118) had evidence of acute infection by SFG Rickettsia spp. Similarly, attending cattle inspection facilities was the most significant risk factor (OR: 8.48, 95% CI: 1.58–45.60). Seropositivity of females showed a significant OR of 8.0 when compared to males (95% CI: 1.49–43.0), and consumption of livestock was associated with a decreased risk (OR: 0.02, 95% CI: 0.001–0.54). A trend between domestic cat contact and SFG rickettsiosis was also noted, albeit borderline non-significant. In this endemic region of South Africa, an understanding of risk factors for zoonotic pathogens, including exposure to domestic animals, can help clinic staff with diagnosis and appropriate therapeutic management of acutely febrile patients as well as identify target areas for education and prevention strategies.

Original languageEnglish (US)
JournalZoonoses and Public Health
DOIs
StatePublished - Jan 1 2019

Fingerprint

Zoonoses
South Africa
fever
Fever
risk factors
pathogens
Q fever
Q Fever
Infection
Logistic Models
infection
Coxiella burnetii
community health
Rickettsia
risk reduction
cattle
Domestic Animals
Livestock
Serology
zoonoses

Keywords

  • one health
  • Q fever
  • questionnaire
  • spotted fever group rickettsiosis
  • tick-borne
  • zoonoses

ASJC Scopus subject areas

  • Epidemiology
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

Risk factors for bacterial zoonotic pathogens in acutely febrile patients in Mpumalanga Province, South Africa. / Berrian, Amanda M.; Martinez Lopez, Beatriz; Quan, Vanessa; Conrad, Patricia A; van Rooyen, Jacques; Simpson, Gregory J.G.; Frean, John; Weyer, Jacqueline; Rossouw, Jennifer; Knobel, Darryn; Blumberg, Lucille.

In: Zoonoses and Public Health, 01.01.2019.

Research output: Contribution to journalArticle

Berrian, Amanda M. ; Martinez Lopez, Beatriz ; Quan, Vanessa ; Conrad, Patricia A ; van Rooyen, Jacques ; Simpson, Gregory J.G. ; Frean, John ; Weyer, Jacqueline ; Rossouw, Jennifer ; Knobel, Darryn ; Blumberg, Lucille. / Risk factors for bacterial zoonotic pathogens in acutely febrile patients in Mpumalanga Province, South Africa. In: Zoonoses and Public Health. 2019.
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