Abstract
Objective-To identify risk factors associated with survival in dogs with nontonsillar oral squamous cell carcinoma (OSCC) that were and were not treated with curative-intent surgery. Design-Retrospective case series. Animals-31 dogs with OSCC. Procedures-Medical records for dogs with OSCC that were not treated, or were treated with curative-intent surgery only between January 1990 and December 2010 were reviewed. For each dog, data regarding signalment, clinical stage, treatment, tumor recurrence, and survival time were obtained from the medical record, and archived biopsy specimens were evaluated to identify the histologic subtype of the tumor and extent of tumor-associated inflammation (TAI), perineural invasion (PNI), and lymphovascular invasion (LVI). Results-Risk of death for the 21 dogs with OSCC that were surgically treated was decreased 91.4% (hazard ratio, 0.086; 95% confidence interval, 0.002 to 0.150), compared with that for the 10 dogs with OSCC that were not treated. The 1-year survival rate was 93.5% and 0% for dogs that were and were not surgically treated, respectively. Risk of death increased significantly with increasing TAI and increasing risk score (combination of TAI, PNI, and LVI). Tumor location, clinical stage, and histologic subtype were not associated with survival time. Conclusions and Clinical Relevance-Results indicated that the prognosis for dogs with OSCC was excellent following surgical excision of the tumor. Risk of death increased with increasing TAI, and combining TAI, PNI, and LVI into a single risk score may be a useful prognostic indicator for dogs with OSCC.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 696-702 |
| Number of pages | 7 |
| Journal | Journal of the American Veterinary Medical Association |
| Volume | 243 |
| Issue number | 5 |
| DOIs | |
| State | Published - Sep 1 2013 |
Fingerprint
ASJC Scopus subject areas
- veterinary(all)
Cite this
Risk factors associated with survival in dogs with nontonsillar oral squamous cell carcinoma : 31 cases (1990-2010). / Fulton, Amy J.; Nemec, Ana; Murphy, Brian G; Kass, Philip H; Verstraete, Frank J.
In: Journal of the American Veterinary Medical Association, Vol. 243, No. 5, 01.09.2013, p. 696-702.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Risk factors associated with survival in dogs with nontonsillar oral squamous cell carcinoma
T2 - 31 cases (1990-2010)
AU - Fulton, Amy J.
AU - Nemec, Ana
AU - Murphy, Brian G
AU - Kass, Philip H
AU - Verstraete, Frank J
PY - 2013/9/1
Y1 - 2013/9/1
N2 - Objective-To identify risk factors associated with survival in dogs with nontonsillar oral squamous cell carcinoma (OSCC) that were and were not treated with curative-intent surgery. Design-Retrospective case series. Animals-31 dogs with OSCC. Procedures-Medical records for dogs with OSCC that were not treated, or were treated with curative-intent surgery only between January 1990 and December 2010 were reviewed. For each dog, data regarding signalment, clinical stage, treatment, tumor recurrence, and survival time were obtained from the medical record, and archived biopsy specimens were evaluated to identify the histologic subtype of the tumor and extent of tumor-associated inflammation (TAI), perineural invasion (PNI), and lymphovascular invasion (LVI). Results-Risk of death for the 21 dogs with OSCC that were surgically treated was decreased 91.4% (hazard ratio, 0.086; 95% confidence interval, 0.002 to 0.150), compared with that for the 10 dogs with OSCC that were not treated. The 1-year survival rate was 93.5% and 0% for dogs that were and were not surgically treated, respectively. Risk of death increased significantly with increasing TAI and increasing risk score (combination of TAI, PNI, and LVI). Tumor location, clinical stage, and histologic subtype were not associated with survival time. Conclusions and Clinical Relevance-Results indicated that the prognosis for dogs with OSCC was excellent following surgical excision of the tumor. Risk of death increased with increasing TAI, and combining TAI, PNI, and LVI into a single risk score may be a useful prognostic indicator for dogs with OSCC.
AB - Objective-To identify risk factors associated with survival in dogs with nontonsillar oral squamous cell carcinoma (OSCC) that were and were not treated with curative-intent surgery. Design-Retrospective case series. Animals-31 dogs with OSCC. Procedures-Medical records for dogs with OSCC that were not treated, or were treated with curative-intent surgery only between January 1990 and December 2010 were reviewed. For each dog, data regarding signalment, clinical stage, treatment, tumor recurrence, and survival time were obtained from the medical record, and archived biopsy specimens were evaluated to identify the histologic subtype of the tumor and extent of tumor-associated inflammation (TAI), perineural invasion (PNI), and lymphovascular invasion (LVI). Results-Risk of death for the 21 dogs with OSCC that were surgically treated was decreased 91.4% (hazard ratio, 0.086; 95% confidence interval, 0.002 to 0.150), compared with that for the 10 dogs with OSCC that were not treated. The 1-year survival rate was 93.5% and 0% for dogs that were and were not surgically treated, respectively. Risk of death increased significantly with increasing TAI and increasing risk score (combination of TAI, PNI, and LVI). Tumor location, clinical stage, and histologic subtype were not associated with survival time. Conclusions and Clinical Relevance-Results indicated that the prognosis for dogs with OSCC was excellent following surgical excision of the tumor. Risk of death increased with increasing TAI, and combining TAI, PNI, and LVI into a single risk score may be a useful prognostic indicator for dogs with OSCC.
UR - http://www.scopus.com/inward/record.url?scp=84883037194&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84883037194&partnerID=8YFLogxK
U2 - 10.2460/javma.243.5.696
DO - 10.2460/javma.243.5.696
M3 - Article
C2 - 23971850
AN - SCOPUS:84883037194
VL - 243
SP - 696
EP - 702
JO - Journal of the American Veterinary Medical Association
JF - Journal of the American Veterinary Medical Association
SN - 0003-1488
IS - 5
ER -