Risk factors associated with survival in dogs with nontonsillar oral squamous cell carcinoma

31 cases (1990-2010)

Amy J. Fulton, Ana Nemec, Brian G Murphy, Philip H Kass, Frank J Verstraete

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Objective-To identify risk factors associated with survival in dogs with nontonsillar oral squamous cell carcinoma (OSCC) that were and were not treated with curative-intent surgery. Design-Retrospective case series. Animals-31 dogs with OSCC. Procedures-Medical records for dogs with OSCC that were not treated, or were treated with curative-intent surgery only between January 1990 and December 2010 were reviewed. For each dog, data regarding signalment, clinical stage, treatment, tumor recurrence, and survival time were obtained from the medical record, and archived biopsy specimens were evaluated to identify the histologic subtype of the tumor and extent of tumor-associated inflammation (TAI), perineural invasion (PNI), and lymphovascular invasion (LVI). Results-Risk of death for the 21 dogs with OSCC that were surgically treated was decreased 91.4% (hazard ratio, 0.086; 95% confidence interval, 0.002 to 0.150), compared with that for the 10 dogs with OSCC that were not treated. The 1-year survival rate was 93.5% and 0% for dogs that were and were not surgically treated, respectively. Risk of death increased significantly with increasing TAI and increasing risk score (combination of TAI, PNI, and LVI). Tumor location, clinical stage, and histologic subtype were not associated with survival time. Conclusions and Clinical Relevance-Results indicated that the prognosis for dogs with OSCC was excellent following surgical excision of the tumor. Risk of death increased with increasing TAI, and combining TAI, PNI, and LVI into a single risk score may be a useful prognostic indicator for dogs with OSCC.

Original languageEnglish (US)
Pages (from-to)696-702
Number of pages7
JournalJournal of the American Veterinary Medical Association
Volume243
Issue number5
DOIs
StatePublished - Sep 1 2013

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squamous cell carcinoma
Squamous Cell Carcinoma
mouth
risk factors
Dogs
neoplasms
dogs
inflammation
Neoplasms
Inflammation
death
Medical Records
surgery
excision
prognosis
biopsy
confidence interval
survival rate
Confidence Intervals
Biopsy

ASJC Scopus subject areas

  • veterinary(all)

Cite this

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title = "Risk factors associated with survival in dogs with nontonsillar oral squamous cell carcinoma: 31 cases (1990-2010)",
abstract = "Objective-To identify risk factors associated with survival in dogs with nontonsillar oral squamous cell carcinoma (OSCC) that were and were not treated with curative-intent surgery. Design-Retrospective case series. Animals-31 dogs with OSCC. Procedures-Medical records for dogs with OSCC that were not treated, or were treated with curative-intent surgery only between January 1990 and December 2010 were reviewed. For each dog, data regarding signalment, clinical stage, treatment, tumor recurrence, and survival time were obtained from the medical record, and archived biopsy specimens were evaluated to identify the histologic subtype of the tumor and extent of tumor-associated inflammation (TAI), perineural invasion (PNI), and lymphovascular invasion (LVI). Results-Risk of death for the 21 dogs with OSCC that were surgically treated was decreased 91.4{\%} (hazard ratio, 0.086; 95{\%} confidence interval, 0.002 to 0.150), compared with that for the 10 dogs with OSCC that were not treated. The 1-year survival rate was 93.5{\%} and 0{\%} for dogs that were and were not surgically treated, respectively. Risk of death increased significantly with increasing TAI and increasing risk score (combination of TAI, PNI, and LVI). Tumor location, clinical stage, and histologic subtype were not associated with survival time. Conclusions and Clinical Relevance-Results indicated that the prognosis for dogs with OSCC was excellent following surgical excision of the tumor. Risk of death increased with increasing TAI, and combining TAI, PNI, and LVI into a single risk score may be a useful prognostic indicator for dogs with OSCC.",
author = "Fulton, {Amy J.} and Ana Nemec and Murphy, {Brian G} and Kass, {Philip H} and Verstraete, {Frank J}",
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T1 - Risk factors associated with survival in dogs with nontonsillar oral squamous cell carcinoma

T2 - 31 cases (1990-2010)

AU - Fulton, Amy J.

AU - Nemec, Ana

AU - Murphy, Brian G

AU - Kass, Philip H

AU - Verstraete, Frank J

PY - 2013/9/1

Y1 - 2013/9/1

N2 - Objective-To identify risk factors associated with survival in dogs with nontonsillar oral squamous cell carcinoma (OSCC) that were and were not treated with curative-intent surgery. Design-Retrospective case series. Animals-31 dogs with OSCC. Procedures-Medical records for dogs with OSCC that were not treated, or were treated with curative-intent surgery only between January 1990 and December 2010 were reviewed. For each dog, data regarding signalment, clinical stage, treatment, tumor recurrence, and survival time were obtained from the medical record, and archived biopsy specimens were evaluated to identify the histologic subtype of the tumor and extent of tumor-associated inflammation (TAI), perineural invasion (PNI), and lymphovascular invasion (LVI). Results-Risk of death for the 21 dogs with OSCC that were surgically treated was decreased 91.4% (hazard ratio, 0.086; 95% confidence interval, 0.002 to 0.150), compared with that for the 10 dogs with OSCC that were not treated. The 1-year survival rate was 93.5% and 0% for dogs that were and were not surgically treated, respectively. Risk of death increased significantly with increasing TAI and increasing risk score (combination of TAI, PNI, and LVI). Tumor location, clinical stage, and histologic subtype were not associated with survival time. Conclusions and Clinical Relevance-Results indicated that the prognosis for dogs with OSCC was excellent following surgical excision of the tumor. Risk of death increased with increasing TAI, and combining TAI, PNI, and LVI into a single risk score may be a useful prognostic indicator for dogs with OSCC.

AB - Objective-To identify risk factors associated with survival in dogs with nontonsillar oral squamous cell carcinoma (OSCC) that were and were not treated with curative-intent surgery. Design-Retrospective case series. Animals-31 dogs with OSCC. Procedures-Medical records for dogs with OSCC that were not treated, or were treated with curative-intent surgery only between January 1990 and December 2010 were reviewed. For each dog, data regarding signalment, clinical stage, treatment, tumor recurrence, and survival time were obtained from the medical record, and archived biopsy specimens were evaluated to identify the histologic subtype of the tumor and extent of tumor-associated inflammation (TAI), perineural invasion (PNI), and lymphovascular invasion (LVI). Results-Risk of death for the 21 dogs with OSCC that were surgically treated was decreased 91.4% (hazard ratio, 0.086; 95% confidence interval, 0.002 to 0.150), compared with that for the 10 dogs with OSCC that were not treated. The 1-year survival rate was 93.5% and 0% for dogs that were and were not surgically treated, respectively. Risk of death increased significantly with increasing TAI and increasing risk score (combination of TAI, PNI, and LVI). Tumor location, clinical stage, and histologic subtype were not associated with survival time. Conclusions and Clinical Relevance-Results indicated that the prognosis for dogs with OSCC was excellent following surgical excision of the tumor. Risk of death increased with increasing TAI, and combining TAI, PNI, and LVI into a single risk score may be a useful prognostic indicator for dogs with OSCC.

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JF - Journal of the American Veterinary Medical Association

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