Risk factors associated with cerebral palsy in preterm infants

Andrea Sukhov, Yvonne Wu, Guibo Xing, Lloyd H Smith, William M. Gilbert

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Objective. To examine pregnancy outcomes in preterm delivered children with cerebral palsy (CP). Methods. A retrospective population-based cohort study of children born in California (January 1, 1991 and December 31, 2001) with CP were identified (State databases) and compared to children without CP. We examined demographic data and pregnancy outcomes by gestational age groups controlling for multiple co-founders. Results. Of 2733 preterm infants (total of 8397, 33% <37 weeks of gestation) with CP, delivery <28 weeks had the largest impact upon the development of CP (Odds ratio (OR) 18.2 95%CI (16.7, 19.9)) with delivery 2831 6/7 weeks having less impact (OR 8.8 (8.0, 9.7) when compared to term deliveries. Birth asphyxia (OR 5.9 (5.3, 6.6) was associated with the future development of CP as were birth defects (OR 4.3 (4.1. 4.5), cord prolapse (OR 2.0 (1.6, 2.4)) and fetal distress (OR 2.1 (1.9, 2.2)) the latter 2 being less so. Conclusion. Prematurity had the greatest impact upon the future development of CP; however, birth asphyxia, birth defects and adverse labor events contributed significantly to the future development of CP as well, suggesting that the cause of CP in the preterm infant is most likely multifactorial.

Original languageEnglish (US)
Pages (from-to)53-57
Number of pages5
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume25
Issue number1
DOIs
StatePublished - Jan 2012

Keywords

  • adverse birth outcomes
  • Asphyxia
  • infection
  • prematurity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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