Risk factors and management of transient tachypnea of the newborn

Transient tachypnea of the newborn (TTN) is the consequence of delayed clearance of fetal lung liquid in the newborn. With recognition of the increased risk in babies born by Cesarean sections, epidemiologic association with maternal asthma and increasing research on the possible role of genetic polymorphisms of ion-channel subunits, our understanding of the pathophysiology of this condition has vastly improved. We now know that the late-preterm infant, born at 34-36 weeks gestation, is at increased risk for both TTN and respiratory distress syndrome due to surfactant deficiency. As the incidence of Cesarean sections rises, there is likelihood of increased respiratory morbidity in newborns that will necessitate additional medical interventions and exposure to complications of intensive care. This review focuses on the risk factors that are associated with the development of TTN and the treatment strategies that are employed for the management of this condition.