Ring opening of sialyllactones with glycine esters: Synthesis of selectively protected glycinyl-NeuAc saccharopeptides

Jacquelyn Gervay-Hague, P. S. Ramamoorthy, Nellie N. Mamuya

Research output: Contribution to journalArticle

14 Scopus citations


Two different classes of sialyllactones were prepared as potential substrates for ring opening reactions with naturally occurring amino acids. The sialyllactones underwent reaction with Glycine ethyl ester hydrochloride salt to afford selectively protected glycine-NeuAc adducts. The reactions could be performed on NeuAc derivatives capable of serving as glycosylation donors. These compounds represent a new class of saccharopeptides, composed of sugar amino acids and naturally occurring amino acids.

Original languageEnglish (US)
Pages (from-to)11039-11048
Number of pages10
Issue number32
StatePublished - Aug 11 1997
Externally publishedYes


ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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